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【结 构 式】 
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【分子编号】66496 【品名】5-(((tetrahydro-2H-pyran-2-yl)peroxy)methyl)oxazolidin-2-one 【CA登记号】 |
【 分 子 式 】C9H15NO5 【 分 子 量 】217.22184 【元素组成】C 49.76% H 6.96% N 6.45% O 36.83% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：(III)
| 【1】 Barhachyn MR. 1995. Substituted oxazine and thiazine oxatotidinone antimicrobials. W01995007271[本专利为Pfrizer Inc (US)所有] |
| 【2】 Brickner SJ, Hutchinson DK, Barbachyn MR, et aL 1996. Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant Gram-positive bacterial infections. J Med Chem, 39 (3): 673～679 |
| 【3】 Du Y.Guo HY. 2002. Synthesis and antibacterial activity of linezolid analogs. Bioorg Med Chem Lett.12(6): 857～859 |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 17015 | 3-fluoro-4-morpholinophenylamine; 3-fluoro-4-morpholinoaniline; 3-fluoro-4-(4-morpholinyl)phenylamine; 3-Fluoro-4-(4-morpholinyl)benzeneamine | 93246-53-8 | C10H13FN2O | 详情 | 详情 |
| (II) | 66495 | 4-(4-bromo-2-fluorophenyl)morpholine | 513068-89-8 | C10H11BrFNO | 详情 | 详情 |
| (III) | 66496 | 5-(((tetrahydro-2H-pyran-2-yl)peroxy)methyl)oxazolidin-2-one | C9H15NO5 | 详情 | 详情 | |
| (IV) | 17018 | (5R)-3-(3-fluoro-4-morpholinophenyl)-5-(hydroxymethyl)-1,3-oxazolan-2-one | 168828-82-8 | C14H17FN2O4 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(III)
| 【1】 Mallesham B, Rajesh BM,Reddy PR, et al. 2003. Highly efficient cui-catalyzed coupling of aryl bromides with oxazolidinones using buchwald's prorocolt: a short route to linezolid and toloxatone. Org Lett,5(7):963～965 |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 17015 | 3-fluoro-4-morpholinophenylamine; 3-fluoro-4-morpholinoaniline; 3-fluoro-4-(4-morpholinyl)phenylamine; 3-Fluoro-4-(4-morpholinyl)benzeneamine | 93246-53-8 | C10H13FN2O | 详情 | 详情 |
| (II) | 66495 | 4-(4-bromo-2-fluorophenyl)morpholine | 513068-89-8 | C10H11BrFNO | 详情 | 详情 |
| (III) | 66496 | 5-(((tetrahydro-2H-pyran-2-yl)peroxy)methyl)oxazolidin-2-one | C9H15NO5 | 详情 | 详情 | |
| (IV) | 66511 | 3-(3-fluoro-4-morpholinophenyl)-5-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)oxazolidin-2-one | C19H25FN2O5 | 详情 | 详情 | |
| (V) | 66512 | 3-(3-fluoro-4-morpholinophenyl)-5-(hydroxymethyl)oxazolidin-2-one | C14H17FN2O4 | 详情 | 详情 |
Extended Information