4-(chloromethyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide -Drug Synthesis Database

【结构式】

【分子编号】66476

【品名】4-(chloromethyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide

【CA登记号】404844-11-7

【分子式】C₂₄H₂₀ClN₅O

【分子量】429.909

【元素组成】C 67.05% H 4.69% Cl 8.25% N 16.29% O 3.72%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VII)

【1】 Kompella A, Bhujanga Rao AKS, Venkaiah Chowdary N, et aL 2004. Process for the preparation of the anti-cancer drug imatinib and its analogs via aminolysis of a (chloromethyl benzamide intermediate. WO 2004108699(本专利申请人为: Natco Pharma Limited, India)
【2】 Szczepek W, Luniewski W, Kaczmarek L, et aL 2006.A process for preparation of imatinib base. W0 2006071130(本专利申请人为: Instytut Farmaceutyczny, Pol)
【3】 Szakacs Z,Beni S,VargaZ,et aL 2005. Acid-base profiling of imatinib(gleevec) and its fragments. J Med Chem,8(1): 249一255
【4】 Zimmermann J.Buchdunger E, Mett H, et aL 1997. Potent and selective inhibitors of the abl-kinase: phenylaminopyrimidine (PAP) derivatives. Bioorg Med Chem Lett,7(2): 187～191

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	47518	2-Amino-4-nitrotoluene; 5-Nitro-o-toluidine; 4-Nitro-2-aminotoluene; 2-methyl-5-nitrophenylamine; 2-methyl-5-nitroaniline	99-55-8	C₇H₈N₂O₂	详情	详情
(II)	47517	N-(2-methyl-5-nitrophenyl)guanidine	152460-07-6	C₈H₁₀N₄O₂	详情	详情
(III)	47516	(E)-3-(dimethylamino)-1-(3-pyridinyl)-2-propen-1-one	123367-26-0	C₁₀H₁₂N₂O	详情	详情
(IV)	47519	N-(2-methyl-5-nitrophenyl)-N-[4-(3-pyridinyl)-2-pyrimidinyl]amine; N-(2-methyl-5-nitrophenyl)-4-(3-pyridinyl)-2-pyrimidinamine	152460-09-8	C₁₆H₁₃N₅O₂	详情	详情
(V)	47520	4-methyl-N(3)-[4-(3-pyridinyl)-2-pyrimidinyl]-1,3-benzenediamine; N-(5-amino-2-methylphenyl)-N-[4-(3-pyridinyl)-2-pyrimidinyl]amine	152460-10-1	C₁₆H₁₅N₅	详情	详情
(VI)	49112	4-(Chloromethyl)benzoyl chloride; p-(Chloromethyl)benzoyl chloride	876-08-4	C₈H₆Cl₂O	详情	详情
(VII)	66476	4-(chloromethyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide	404844-11-7	C₂₄H₂₀ClN₅O	详情	详情
(VIII)	10061	1-Methylpiperazine; 1-Methyl piperazine; N-Methylpiperazine	109-01-3	C₅H₁₂N₂	详情	详情

Extended Information