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【结 构 式】 
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【分子编号】66453 【品名】tert-butyl 3-cyano-4-(methoxyimino)pyrrolidine-1-carboxylate 【CA登记号】 |
【 分 子 式 】C11H17N3O3 【 分 子 量 】239.2744 【元素组成】C 55.22% H 7.16% N 17.56% O 20.06% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)
| 【1】 Cho SW, Choi HY, Hayler JD 2001. Process for production of naphthyridine-3-carboxylic acid derivatives. W0 2001018002（本专利为Sb Phdmco Puerto Rico Inc, USA; Lg Chmucal Ltd所有） |
| 【2】 Hwang G-H, Kim Y-D, Nam H, et aL 2004. Process for preparing 4-aminomethyl-3-alkoxyinunopyrrolidine methanesulfonates from N-protected 4-cyano-3-moopyrrolidines and (halo) alkoxyamines. WO 2004092129(本专利申请人为LG Life Sciences Ltd,SKorea) |
| 【3】 Noh HK, Lee JS, Kim Y, et 81.2004. Synthesis of the intermediate of gemifloxacin by the chemoselective hydrogenation of 4-cyano-3-metboxyimino-l-(N-tert-butoxycarlxmyl) pyrrolidine. Part 1.Screening of metal catalysts. Org Proc Res Dev,8(5)1 781~787 |
| 【4】 Noh HK, Lee JS, Kim Y, et aL 2004. Synthesis of the intermediate ofgemifloxacin by the chemoselective hydrogenationof 4-cyano-3-methoxyimino-l-(N-tert-butoxycarbonyl) pyrrolidine. Part 2.The palladium catalysts in acidic media. Org Proc Res Dev,8(5): 788~795 |
| 【5】 Parthasaradhi RB, Rathnakar RK, R.aji RR, et aL 2006. Process for the preparation of amorphous gemifloxacin and its polymorphs for use infusion solutions. W0 2006134608(奉专利申请人为Hetero Drugs Limited, India) |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 17732 | tert-butyl 3-cyano-4-oxo-1-pyrrolidinecarboxylate | C10H14N2O3 | 详情 | 详情 | |
| (II) | 66453 | tert-butyl 3-cyano-4-(methoxyimino)pyrrolidine-1-carboxylate | C11H17N3O3 | 详情 | 详情 | |
| (III) | 66454 | tert-butyl 3-(aminomethyl)-4-(methoxyimino)pyrrolidine-1-carboxylate | C11H21N3O3 | 详情 | 详情 | |
| (IV) | 17738 | 4-(aminomethyl)-3-pyrrolidinone O-methyloxime | C6H13N3O | 详情 | 详情 |
Extended Information