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【结 构 式】

【分子编号】66437

【品名】4-methoxy-3-(3-morpholinopropoxy)benzaldehyde

【CA登记号】861453-11-4

【 分 子 式 】C15H21NO4

【 分 子 量 】279.33608

【元素组成】C 64.5% H 7.58% N 5.01% O 22.91%

与该中间体有关的原料药合成路线共 2 条

合成路线1

该中间体在本合成路线中的序号:(II)

 

1 Jyothi Prasad R. 2005. An improved process for the preparation of gefitinib. WO2005023783(本专利为Natco Pharma Ltd所有)
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 18455 3-hydroxy-4-methoxybenzaldehyde; Isovanillin 621-59-0 C8H8O3 详情 详情
(II) 66437 4-methoxy-3-(3-morpholinopropoxy)benzaldehyde 861453-11-4 C15H21NO4 详情 详情
(III) 66438 4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzaldehyde   C15H20N2O6 详情 详情
(IV) 66439 (Z)-4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzaldehyde oxime   C15H21N3O6 详情 详情
(V) 66434 4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile 675126-26-8 C15H19N3O5 详情 详情
(VI) 66440 4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzamide   C15H21N3O6 详情 详情
(VII) 66441 2-amino-4-methoxy-5-(3-morpholinopropoxy)benzamide   C15H23N3O4 详情 详情
(VIII) 66442 7-methoxy-6-(3-morpholinopropoxy)quinazolin-4(3H)-one   C16H21N3O4 详情 详情
(IX) 66443 4-(3-((4-chloro-7-methoxyquinazolin-6-yl)oxy)propyl)morpholine   C16H20ClN3O3 详情 详情
(X) 18688 3-Chloro-4-fluorophenylamine; 3-Chloro-4-fluoroaniline 367-21-5 C6H5ClFN 详情 详情

合成路线2

该中间体在本合成路线中的序号:(III)

 

1 Chandregowda V,Rao GV, Reddy GC. 2007. One-pot conversion of 2-nitrobenzonitriles to quinazolin-4(3H)-ones and synthesis of gefitinib and erlotinib hydrochloride. Heterocycles,71(1): 39~48
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 18455 3-hydroxy-4-methoxybenzaldehyde; Isovanillin 621-59-0 C8H8O3 详情 详情
(II) 18691 4-(3-chloropropyl)morpholine;N-(3-Chloropropyl)morpholine 7357-67-7 C7H14ClNO 详情 详情
(III) 66437 4-methoxy-3-(3-morpholinopropoxy)benzaldehyde 861453-11-4 C15H21NO4 详情 详情
(IV) 66444 (Z)-4-methoxy-3-(3-morpholinopropoxy)benzaldehyde oxime   C15H22N2O4 详情 详情
(V) 66433 4-methoxy-3-(3-morpholinopropoxy)benzonitrile   C15H20N2O3 详情 详情
(VI) 66434 4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile 675126-26-8 C15H19N3O5 详情 详情
(VII) 66445 7-methoxy-6-(3-morpholinopropoxy)quinazolin-4(1H)-one   C16H21N3O4 详情 详情
(VIII) 18688 3-Chloro-4-fluorophenylamine; 3-Chloro-4-fluoroaniline 367-21-5 C6H5ClFN 详情 详情
Extended Information