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【结 构 式】 
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【分子编号】66406 【品名】(4aR,8aR)-3-methoxy-5,6,9,10-tetrahydro-4aH-benzo[2,3]benzofuro[4,3-cd]azepin-6-ol 【CA登记号】 |
【 分 子 式 】C16H17NO3 【 分 子 量 】271.31592 【元素组成】C 70.83% H 6.32% N 5.16% O 17.69% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(X)
| 【1】 Kodama S,Hamashima Y,Nishide K.et aL 2004. Total synthesis of (-)-galanthanune by remote asymmetric induction. Angew Chem lnt Ed, 43 (20L 2659~2661 |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 12874 | (2R)-2-[(tert-Butoxycarbonyl)amino]-3-phenylpropionic acid; N-alpha-t-BOC-L-Phenylalanine | 13734-34-4 | C14H19NO4 | 详情 | 详情 |
| (II) | 19988 | 4-(2-Aminoethyl)phenol; Tyramine | 51-67-2 | C8H11NO | 详情 | 详情 |
| (III) | 66399 | (S)-tert-butyl (1-((4-hydroxyphenethyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate | C22H28N2O4 | 详情 | 详情 | |
| (IV) | 66400 | (S)-2-amino-N-(4-hydroxyphenethyl)-3-phenylpropanamide | C17H20N2O2 | 详情 | 详情 | |
| (V) | 66401 | (2R,5S)-5-benzyl-2-(3,5-bis(benzyloxy)-4-methoxyphenyl)-3-(4-hydroxyphenethyl)imidazolidin-4-one | C39H38N2O5 | 详情 | 详情 | |
| (VI) | 66402 | (2S,5S)-5-benzyl-2-(3,5-bis(benzyloxy)-4-methoxyphenyl)-3-(4-hydroxyphenethyl)-1-(2,2,2-trifluoroacetyl)imidazolidin-4-one | C41H37F3N2O6 | 详情 | 详情 | |
| (VII) | 66403 | (2S,11bS)-2-benzyl-8,10-bis(benzyloxy)-9-methoxy-1-(2,2,2-trifluoroacetyl)-1,5,6,11b-tetrahydrospiro[benzo[c]imidazo[1,2-a]azepine-7,1'-cyclohexa[2,5]diene]-3,4'(2H)-dione | C41H35F3N2O6 | 详情 | 详情 | |
| (VIII) | 66404 | (2S,3aS,7aR,11aR)-2-benzyl-5-hydroxy-6-methoxy-3-(2,2,2-trifluoroacetyl)-3,3a,7a,8,12,13-hexahydro-1H-benzo[2,3]benzofuro[4,3-cd]imidazo[1,2-a]azepine-1,9(2H)-dione | C27H23F3N2O6 | 详情 | 详情 | |
| (IX) | 66405 | (2S,3aS,7aR,11aR)-2-benzyl-6-methoxy-3-(2,2,2-trifluoroacetyl)-3,3a,7a,8,12,13-hexahydro-1H-benzo[2,3]benzofuro[4,3-cd]imidazo[1,2-a]azepine-1,9(2H)-dione | C27H23F3N2O5 | 详情 | 详情 | |
| (X) | 66406 | (4aR,8aR)-3-methoxy-5,6,9,10-tetrahydro-4aH-benzo[2,3]benzofuro[4,3-cd]azepin-6-ol | C16H17NO3 | 详情 | 详情 |
Extended Information