2,2,2-trifluoro-N-(3-hydroxy-2-methyl-6-((3,5,12-trihydroxy-3-(2-hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl)oxy)tetrahydro-2H-pyran-4-yl)acetamide -Drug Synthesis Database

【结构式】

【分子编号】66345

【品名】2,2,2-trifluoro-N-(3-hydroxy-2-methyl-6-((3,5,12-trihydroxy-3-(2-hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl)oxy)tetrahydro-2H-pyran-4-yl)acetamide

【CA登记号】　

【分子式】C₂₉H₂₈F₃NO₁₂

【分子量】639.536

【元素组成】C 54.46% H 4.41% F 8.91% N 2.19% O 30.02%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XI)

参考文献中间体

合成目标

【1】 Van Der Rijst M, Scheeren JW, et aL.1998. A process for preparing epirubicin or acid addition salts thereof from daunorubicin. EP 848009

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	66341	(8S,10S)-8-acetyl-10-((4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride		C₂₇H₂₉NO₁₀.HCl	详情	详情
(II)	16223	(8S,10S)-8-acetyl-6,8,10,11-tetrahydroxy-1-methoxy-7,8,9,10-tetrahydro-5,12-naphthacenedione	21794-55-8	C₂₁H₁₈O₈	详情	详情
(III)	66342	4-amino-6-methoxy-2-methyltetrahydro-2H-pyran-3-ol hydrochloride		C₇H₁₅NO₃.HCl	详情	详情
(IV)	66346	2-oxo-2-(2,4,5,12-tetrahydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl)ethyl acetate		C₂₃H₂₀O₁₀	详情	详情
(V)	30693	2,2,2-trifluoro-N-[(2S,3S,4S,6R)-3-hydroxy-6-methoxy-2-methyltetrahydro-2H-pyran-4-yl]acetamide		C₉H₁₄F₃NO₄	详情	详情
(VI)	30694	2,2,2-trifluoro-N-[(2S,4S,6R)-6-methoxy-2-methyl-3-oxotetrahydro-2H-pyran-4-yl]acetamide		C₉H₁₂F₃NO₄	详情	详情
(VII)	30695	2,2,2-trifluoro-N-[(2S,3R,4S,6R)-3-hydroxy-6-methoxy-2-methyltetrahydro-2H-pyran-4-yl]acetamide		C₉H₁₄F₃NO₄	详情	详情
(VIII)	30696	N-[(2S,3R,4S,6R)-3,6-dihydroxy-2-methyltetrahydro-2H-pyran-4-yl]-2,2,2-trifluoroacetamide		C₈H₁₂F₃NO₄	详情	详情
(IX)	66343	5-hydroxy-6-methyl-4-(2,2,2-trifluoroacetamido)tetrahydro-2H-pyran-2-yl 2,2,2-trifluoroacetate		C₁₀H₁₁F₆NO₅	详情	详情
(X)	66344	2-oxo-2-(2,5,12-trihydroxy-4-((5-hydroxy-6-methyl-4-(2,2,2-trifluoroacetamido)tetrahydro-2H-pyran-2-yl)oxy)-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl)ethyl acetate		C₃₁H₃₀F₃NO₁₃	详情	详情
(XI)	66345	2,2,2-trifluoro-N-(3-hydroxy-2-methyl-6-((3,5,12-trihydroxy-3-(2-hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl)oxy)tetrahydro-2H-pyran-4-yl)acetamide		C₂₉H₂₈F₃NO₁₂	详情	详情
(XII)	30701	2,2,2-trifluoro-N-[(2S,3R,4S,6R)-3-hydroxy-2-methyl-6-([(1S,3S)-3,5,12-trihydroxy-10-methoxy-3-[(4R)-4-methoxy-2,2-dimethyl-1,3-dioxolan-4-yl]-6,11-dioxo-1,2,3,4,6,11-hexahydro-1-naphthacenyl]oxy)tetrahydro-2H-pyran-4-yl]acetamide		C₃₃H₃₆F₃NO₁₃	详情	详情

Extended Information