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【结 构 式】 
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【分子编号】65810 【品名】N-Methylphenylacetohydroxamic Acid; N-Hydroxy-N-Methyl-2-Phenyl-Acetamide; N-Hydroxy-N-Methyl-2-Phenyl-Ethanamide 【CA登记号】72229-75-5 |
【 分 子 式 】C9H11NO2 【 分 子 量 】165.19188 【元素组成】C 65.44% H 6.71% N 8.48% O 19.37% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XIV)The bromo amide intermediate (XI) is prepared by condensation of phenylacetyl chloride (XIII) with N-methylhydroxylamine hydrochloride in the presence of Et3N in CH2Cl2 to produce the Weinreb amide (XIV), which is then acylated with methanesulfonyl chloride and Et3N followed by ultrasound-promoted rearrangement of the N-sulfonyloxy amide intermediate in the presence of DIEA and LiBr in acetonitrile (1). Scheme 2.
| 【1】 Weller, T., Koberstein, R., Aissaoui, H., Clozel, M., Fischli, W. (Actelion Pharmaceuticals Ltd.). Substituted 1,2,3,4-tetrahydroisoquinoline derivatives. EP 1751111, JP 2007525531, US 2007191424, WO 2005118548. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XI) | 65808 | 2-Bromo-N-Methyl-2-Phenyl-Acetamide | 51685-62-2 | C9H10BrNO | 详情 | 详情 |
| (XIII) | 25890 | 2-phenylacetyl chloride；Phenylacetyl chloride;Phenacetyl chloride;Benzeneacetyl chloride | 103-80-0 | C8H7ClO | 详情 | 详情 |
| (XIV) | 65810 | N-Methylphenylacetohydroxamic Acid; N-Hydroxy-N-Methyl-2-Phenyl-Acetamide; N-Hydroxy-N-Methyl-2-Phenyl-Ethanamide | 72229-75-5 | C9H11NO2 | 详情 | 详情 |
Extended Information