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【结 构 式】 
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【分子编号】65532 【品名】 【CA登记号】 |
【 分 子 式 】C12H17NO2 【 分 子 量 】207.27252 【元素组成】C 69.54% H 8.27% N 6.76% O 15.44% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XII)In a related strategy, the precursor di-tert-butyl combretastatin A-4 phosphate (Va) is prepared by protection of isovanillin (XI) as the corresponding imine (XII) with butylamine and p-toluenesulfonic acid, followed by phosphitylation with di-tert-butyl N,N-diethylphosphoramidite in the presence of tetrazole, and oxidation to phosphate (XIII) with m-chloroperbenzoic acid. Subsequent Wittig reaction of aldehyde (XIII) with 3,4,5-trimethoxybenzyl triphenylphosphonium bromide (VIII) produces the target stilbene phosphate derivative (Va) (6). Scheme 3.
| 【6】 Griffin, R.J., Quarterman, C.P., Rathbone, D.L., Slack, J.A. (Aston Molecules Ltd.). Substd. diphenylethylenes and analogues of derivs. thereof. WO 9216486. |
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