【结 构 式】 |
【分子编号】65184 【品名】3-fluoro-4-methoxybenzaldehyde 【CA登记号】351-54-2 |
【 分 子 式 】C8H7FO2 【 分 子 量 】154.1407832 【元素组成】C 62.34% H 4.58% F 12.33% O 20.76% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:Treatment of 4-(acetylamino)phenylsulfonyl chloride (I) with tert-butylamine yields sulfonamide (II), which on deprotection with potassium hydroxide gives amine (III). Reaction of compound (III) with 4-methoxy-3-fluorobenz-aldehyde gives imine (IV), which is cyclized with tosylmethyl isocyanide to afford imidazole (V). Regioselective chlorination of compound (V) with N-chlorosuccinimide (NCS) to afford the chloroimidazole (VI) and then deprotection of the sulfonamide group of (VI) yields cimicoxib in 40% overall yield.
【1】 Almansa, C.; Torres, M.C.; Gonzalez, C. (J. Uriach & Cia., SA); Novel imidazoles with anti-inflammatory activity. EP 1122243; JP 2002527508; WO 0023426 . |
【2】 Almansa Rosales, C.; Gonzales Gonzales, C. (J. Uriach & Cia., SA); Method of preparing 4-(imidazol-1-yl)benzenesulphonamide derivs.. ES 2184633; WO 0316285 . |
【3】 Sorbera, L.A., Ramis, I.; Cimicoxib. Drugs Fut 2004, 29 (4): 325. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
65184 | 3-fluoro-4-methoxybenzaldehyde | 351-54-2 | C8H7FO2 | 详情 | 详情 | |
(I) | 19362 | 4-(acetamido)benzenesulfonyl chloride; N-acetylsulfanilyl chloride | 121-60-8 | C8H8ClNO3S | 详情 | 详情 |
(II) | 65182 | N-{4-[(tert-butylamino)sulfonyl]phenyl}acetamide | C12H18N2O3S | 详情 | 详情 | |
(III) | 65183 | 4-amino-N-(tert-butyl)benzenesulfonamide | 209917-48-6 | C10H16N2O2S | 详情 | 详情 |
(IV) | 65185 | N-(tert-butyl)-4-{[(Z)-(3-fluoro-4-methoxyphenyl)methylidene]amino}benzenesulfonamide | C18H21FN2O3S | 详情 | 详情 | |
(V) | 65186 | N-(tert-butyl)-4-[5-(3-fluoro-4-methoxyphenyl)-1H-imidazol-1-yl]benzenesulfonamide | C20H22FN3O3S | 详情 | 详情 | |
(VI) | 65187 | N-(tert-butyl)-4-[4-chloro-5-(3-fluoro-4-methoxyphenyl)-1H-imidazol-1-yl]benzenesulfonamide | C20H21ClFN3O3S | 详情 | 详情 |
Extended Information