N-(2-methoxyphenyl)benzenecarboximidamide -Drug Synthesis Database

【结构式】

【分子编号】65126

【品名】N-(2-methoxyphenyl)benzenecarboximidamide

【CA登记号】

【分子式】C₁₄H₁₄N₂O

【分子量】226.27804

【元素组成】C 74.31% H 6.24% N 12.38% O 7.07%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

Condensation between ortho-anisidine (I) and benzonitrile (II) in the presence of NaNH2 furnishes N-(2-methoxyphenyl)benzamidine (III). Subsequent condensation of (III) with p-tolyl isothiocyanate (IV) produces the imidoyl thiourea (V). This is then oxidized by bromine in CHCl3 to form the target thiadiazolium salt.

参考文献中间体

合成目标

【1】 Pan, K.; Scott, M.K.; Lee, D.H.S.; Fitzpatrick, L.J.; Crooke, J.J.; Rivero, R.A.; Rosenthal, D.I.; Vaidya, A.H.; Zhao, B.; Reitz, A.B.; 2,3-Diaryl-5-anilino[1,2,4]thiadiazoles as melanocortin MC4 receptor agonists and their effects on feeding behavior in rats. Bioorg Med Chem 2003, 11, 2, 185.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	25193	2-methoxyphenylamine; 2-methoxyaniline	517-28-2	C₇H₉NO	详情	详情
(II)	25904	benzonitrile	100-47-0	C₇H₅N	详情	详情
(III)	65126	N-(2-methoxyphenyl)benzenecarboximidamide		C₁₄H₁₄N₂O	详情	详情
(IV)	51389	1-isothiocyanato-4-methylbenzene; 4-methylphenyl isothiocyanate		C₈H₇NS	详情	详情
(V)	65128	N-[(Z)-(2-methoxyanilino)(phenyl)methylidene]-N'-(4-methylphenyl)thiourea		C₂₂H₂₁N₃OS	详情	详情

Extended Information