【结 构 式】 |
【分子编号】64982 【品名】6-chloro-9-{[2-(methyloxy)phenyl]methyl}-9H-purin-2-amine; 6-chloro-9-{[2-(methyloxy)phenyl]methyl}-9H-purin-2-ylamine 【CA登记号】 |
【 分 子 式 】C13H12ClN5O 【 分 子 量 】289.72408 【元素组成】C 53.89% H 4.17% Cl 12.24% N 24.17% O 5.52% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(III)Alkylation of 2-amino-6-chloropurine (I) with 2-methoxybenzyl chloride (II) in the presence of K2CO3 and Bu4NI gives the 9-substituted purine (III). Amino purine (III) is converted into the corresponding 2-iodo derivative (IV) by treatment with isoamyl nitrite in hot diiodomethane. Finally, displacement of the 6-chloro group of (IV) with methylamine furnishes the desired adenine derivative.
【1】 Raboisson, P.; Lugnier, C.; Muller, C.; Reimund, J.-M.; Schultz, D.; Pinna, G.; Le Bec, A.; Basaran, H.; Desaubry, L.; Gaudiot, F.; Seloum, M.; Bourguignon, J.-J.; Design, synthesis and structure-activity relationships of a series of 9-substituted adenine derivatives as selective phosphodiesterase type-4 inhibitors. Eur J Med Chem 2003, 38, 2, 199. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 11644 | 6-Chloro-9H-purin-2-amine; 6-Chloro-9H-purin-2-ylamine; 2-Amino-6-chloropurine | 10310-21-1 | C5H4ClN5 | 详情 | 详情 |
(II) | 31017 | 2-(chloromethyl)phenyl methyl ether; 1-(chloromethyl)-2-methoxybenzene | 7035-02-1 | C8H9ClO | 详情 | 详情 |
(III) | 64982 | 6-chloro-9-{[2-(methyloxy)phenyl]methyl}-9H-purin-2-amine; 6-chloro-9-{[2-(methyloxy)phenyl]methyl}-9H-purin-2-ylamine | C13H12ClN5O | 详情 | 详情 | |
(IV) | 64983 | 2-[(6-chloro-2-iodo-9H-purin-9-yl)methyl]phenyl methyl ether; 6-chloro-2-iodo-9-{[2-(methyloxy)phenyl]methyl}-9H-purine | C13H10ClIN4O | 详情 | 详情 |
Extended Information