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【结 构 式】

【分子编号】64930

【品名】3-{[(1,1-dimethylethyl)(diphenyl)silyl]oxy}-2-(methyloxy)propanoic acid

【CA登记号】

【 分 子 式 】C20H26O4Si

【 分 子 量 】358.50954

【元素组成】C 67.01% H 7.31% O 17.85% Si 7.83%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XXXII)

Synthesis of dysinosin A: The reaction of the commercially available D-mannitol derivative (XXVII) with NaH and MeI in DMF gives the dimethoxy compound (XXVIII), which is hydrogenated with H2 over Pd/C in EtOH/EtOAc to yield the dimethoxy-D-mannitol (XXIX). The selective silylation of the primary OH groups of (XXIX) with Tbdps-Cl and imidazole affords the bis silyl ether (XXX), which is submitted to an oxidative cleavage of its vicinal diol group by means of Pb(OAc)4 to provide 2(R)-methoxy-3-(Tbdps-O)propanal (XXXI) (3). The oxidation of (XXXI) with NaClO2 gives the corresponding carboxylic acid (XXXII), which is condensed with D-leucine benzyl ester (XXXIII) by means of EDC and HOBt in dichloromethane to yield adduct (XXXIV). The reductive cleavage of the benzyl group of (XXXIV) with H2 over Pd/C in methanol affords the substituted leucine (XXXV), which is condensed with the perhydroindole intermediate (XIII) by means of Bop-Cl and DIEA in acetonitrile to provide the amide (XXXVI). The hydrolysis of the methyl ester group of (XXXVI) with LiOH in THF/MeOH gives the carboxylic acid (XXXVII), which is condensed with the aminoethyl-3-pyrroline intermediate (XXVI) by means of EDC and HOBt in dichloromethane to yield the amide intermediate (XXXVIII). The cleavage of the silyl ether group of (XXXVIII) by means of TBAF in THF affords the primary alcohol (XXXIX), which is treated with Pyr/SO3 and Bu2SnO to provide the sulfate ester (XL). Finally, this compound is fully deprotected by means of TFA in dichloromethane and purified by means of preparative HPLC to obtain the target dysinosin A (2).

1 Nicolaou, K.C.; Piscopio, A.D.; Bertinato, P.; Chakraborty, T.K.; Minowa, N.; Koide, K.; Total Synthesis of Rapamycin. Chemistry (Weinheim) 1995, 1, 5, 318.
2 Hanessian, S.; Margarita, R.; Hall, A.; Johnstone, S.; Tremblay, M.; Parlanti, L.; Total synthesis and structural confirmation of the marine natural product Dysinosin A: A novel inhibitor of thrombin and Factor VIIa. J Am Chem Soc 2002, 124, 45, 13342.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(XIII) 64913 methyl 5,6-bis{[(methyloxy)methyl]oxy}octahydro-1H-indole-2-carboxylate C14H25NO6 详情 详情
(XXVI) 64925   C17H30N4O4 详情 详情
(XXVII) 64926   C20H22O6 详情 详情
(XXVIII) 64927   C22H26O6 详情 详情
(XXIX) 64928 2,5-bis(methyloxy)-1,3,4,6-hexanetetrol C8H18O6 详情 详情
(XXX) 64929 2,2,13,13-tetramethyl-6,9-bis(methyloxy)-3,3,12,12-tetraphenyl-4,11-dioxa-3,12-disilatetradecane-7,8-diol C40H54O6Si2 详情 详情
(XXXI) 15026 (2R)-3-[[tert-butyl(diphenyl)silyl]oxy]-2-methoxypropanal C20H26O3Si 详情 详情
(XXXII) 64930 3-{[(1,1-dimethylethyl)(diphenyl)silyl]oxy}-2-(methyloxy)propanoic acid C20H26O4Si 详情 详情
(XXXIII) 28648 benzyl (2R)-2-amino-4-methylpentanoate C13H19NO2 详情 详情
(XXXIV) 64931 phenylmethyl 2-{[3-{[(1,1-dimethylethyl)(diphenyl)silyl]oxy}-2-(methyloxy)propanoyl]amino}-4-methylpentanoate C33H43NO5Si 详情 详情
(XXXV) 64932 N-[3-{[(1,1-dimethylethyl)(diphenyl)silyl]oxy}-2-(methyloxy)propanoyl]leucine C26H37NO5Si 详情 详情
(XXXVI) 64933 methyl 1-(2-{[2-{[(1,1-dimethylethyl)(diphenyl)silyl]oxy}-2-(methyloxy)acetyl]amino}-4-methylpentanoyl)-5,6-bis{[(methyloxy)methyl]oxy}octahydro-1H-indole-2-carboxylate C39H58N2O10Si 详情 详情
(XXXVII) 64934 1-(2-{[2-{[(1,1-dimethylethyl)(diphenyl)silyl]oxy}-2-(methyloxy)acetyl]amino}-4-methylpentanoyl)-5,6-bis{[(methyloxy)methyl]oxy}octahydro-1H-indole-2-carboxylic acid C38H56N2O10Si 详情 详情
(XXXVIII) 64935   C55H84N6O13Si 详情 详情
(XXXIX) 64936   C39H66N6O13 详情 详情
(XL) 64937 2-{[(2-{1-[({[(1,1-dimethylethyl)oxy]carbonyl}amino)({[(1,1-dimethylethyl)oxy]carbonyl}imino)methyl]-2,5-dihydro-1H-pyrrol-3-yl}ethyl)amino]carbonyl}-1-(4-methyl-2-{[2-(methyloxy)-2-(sulfonatooxy)acetyl]amino}pentanoyl)-5,6-bis{[(methyloxy)methyl]ox C39H65N6O16S 详情 详情
Extended Information