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【结 构 式】 
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【分子编号】64864 【品名】 【CA登记号】 |
【 分 子 式 】C41H64O10Si2 【 分 子 量 】773.12416 【元素组成】C 63.7% H 8.34% O 20.69% Si 7.27% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)Protection of 10-deacetylbaccatin III (I) with chlorotriethylsilane in pyridine affords the 7,13-bis-silyl ether (II), which upon alkylation by means of iodomethane and NaH provides the 10-methoxy derivative (III). After desilylation of (III) by means of a hydrogen fluoride-triethylamine complex, the deprotected triol (IV) is methylated with iodomethane and NaH to yield the 7,10-dimethyl ether (V). Esterification of (V) with the oxazolidinecarboxylic acid (VI) in the presence of DCC/DMAP furnishes (VII). (1,2)
| 【1】 Bouchard, H.; Bourzat, J.-D.; Commerçon, A. (Aventis Pharma SA); Novel taxoids, preparation thereof and pharmaceutical compsns. containing same. EP 0817779; EP 0817780; FR 2732340; JP 1999500141; JP 1999502531; US 5889043; US 6372780; US 6387946; WO 9630355; WO 9630356 . |
| 【2】 Bissery, M.-C. (Aventis Pharma SA); Use of taxoid derivs.. EP 1020188; EP 1140064; US 2002082291; US 6403634; WO 0041482 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 64863 | 4-(acetyloxy)-1,9,12,15-tetrahydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0~3,10~.0~4,7~]heptadec-13-en-2-yl benzoate | C29H36O10 | 详情 | 详情 | |
| (II) | 64864 | C41H64O10Si2 | 详情 | 详情 | ||
| (III) | 64865 | C42H66O10Si2 | 详情 | 详情 | ||
| (IV) | 64866 | C30H38O10 | 详情 | 详情 | ||
| (V) | 64867 | C31H40O10 | 详情 | 详情 | ||
| (VI) | 64868 | 3-{[(1,1-dimethylethyl)oxy]carbonyl}-2-[4-(methyloxy)phenyl]-4-phenyl-1,3-oxazolidine-5-carboxylic acid | C22H25NO6 | 详情 | 详情 | |
| (VII) | 64869 | C53H63NO15 | 详情 | 详情 |
Extended Information