4-(methylamino)benzoic acid -Drug Synthesis Database

【结构式】

【分子编号】64844

【品名】4-(methylamino)benzoic acid

【CA登记号】

【分子式】C₈H₉NO₂

【分子量】151.165

【元素组成】C 63.56% H 6% N 9.27% O 21.17%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

Condensation of 2-amino-5-methoxythiophenol (I) with 4-(methylamino)benzoic acid (II) in hot polyphosphoric acid produces the benzothiazole derivative (III), which is finally submitted to methyl ether cleavage by means of BBr3 to give the target hydroxy compound.

参考文献中间体

合成目标

【1】 Mathis, C.A.; Wang, Y.; Holt, D.P.; Huang, G.-F.; Debnath, M.L.; Klunk, W.E.; Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents. J Med Chem 2003, 46, 13, 2740.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	25876	2-amino-5-methoxyphenylhydrosulfide; 5-Methoxy-2-aminothiophenol;2-Mercapto-4-methoxyaniline;2-amino-5-methoxybenzenethiol；2-Amino-5-methoxy-1-benzenethiol	6274-29-9	C₇H₉NOS	详情	详情
(II)	64844	4-(methylamino)benzoic acid		C₈H₉NO₂	详情	详情
(III)	64845	4-(6-methoxy-1,3-benzothiazol-2-yl)-N-methylaniline; N-[4-(6-methoxy-1,3-benzothiazol-2-yl)phenyl]-N-methylamine		C₁₅H₁₄N₂OS	详情	详情

Extended Information