【结 构 式】 |
【分子编号】65103 【品名】2-amino-6-[2-(trimethylsilyl)ethynyl]-4-quinazolinylamine; 6-[2-(trimethylsilyl)ethynyl]-2,4-quinazolinediamine 【CA登记号】 |
【 分 子 式 】C13H16N4Si 【 分 子 量 】256.3825 【元素组成】C 60.9% H 6.29% N 21.85% Si 10.95% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(III)Palladium-catalyzed coupling of 2,4-diamino-6-iodoquinazoline (I) with trimethylsilyl acetylene (II) affords the silylethynyl quinazoline (III). Subsequent treatment of (III) with tetrabutylammonium fluoride leads to the desilylated acetylene compound (IV).
【1】 Vaidya, C.M.; Wright, J.E.; Rosowsky, A.; Synthesis and in vitro antitumor activity of new deaza analogues of the nonpolyglutamatable antifolate Nalpha-(4-amino-4-deoxypteroyl)-Nalpha-hemiphtaloyl-L-ornithine (PT523). J Med Chem 2002, 45, 8, 1690. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 65105 | 2-amino-6-iodo-4-quinazolinylamine; 6-iodo-2,4-quinazolinediamine | C8H7IN4 | 详情 | 详情 | |
(II) | 51602 | 1-Propyne | C3H4 | 详情 | 详情 | |
(III) | 65103 | 2-amino-6-[2-(trimethylsilyl)ethynyl]-4-quinazolinylamine; 6-[2-(trimethylsilyl)ethynyl]-2,4-quinazolinediamine | C13H16N4Si | 详情 | 详情 | |
(IV) | 65104 | 2-amino-6-ethynyl-4-quinazolinylamine; 6-ethynyl-2,4-quinazolinediamine | C10H8N4 | 详情 | 详情 |
Extended Information