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【结 构 式】 
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【分子编号】65092 【品名】(4R)-3-((2S,4R)-4-benzyl-2-{[tert-butyl(dimethyl)silyl]oxy}-5-{[(3S,4S)-3-hydroxy-3,4-dihydro-2H-chromen-4-yl]amino}-5-oxopentanoyl)-N-[(3,5-dimethyl-4-isothiazolyl)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide 【CA登记号】 |
【 分 子 式 】C39H54N4O6S2Si 【 分 子 量 】767.09862 【元素组成】C 61.07% H 7.1% N 7.3% O 12.51% S 8.36% Si 3.66% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XIV)Coupling of acid (XII) with (S,S)-4-aminochroman-3-ol (XIII) in the presence of HBTU provides amide (XIV). Finally, desilylation of (XIV) with tetrabutylammonium fluoride gives rise to the target compound.
| 【1】 Bohn, J.; Lu, Z.; Raghavan, S.; Charest, M.; Stahlhut, M.; Rutkowski, C.A.; Himmelberger, A.L.; Olsen, D.B.; Scheleif, W.A.; Carella, A.; Gabryelski, L.; Jin, L.; Lin, J.H.; Tata, J.R.; Chapman, K.; Synthesis of highly potent HIV protease inhibitors with activity against protease resistant virus. 224th ACS Natl Meet (Aug 18 2002, Boston) 2002, Abst MEDI 205. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XII) | 65062 | (2R,4S)-2-benzyl-4-{[tert-butyl(dimethyl)silyl]oxy}-5-[(4R)-4-({[(3,5-dimethyl-4-isothiazolyl)methyl]amino}carbonyl)-5,5-dimethyl-1,3-thiazolidin-3-yl]-5-oxopentanoic acid | C30H45N3O5S2Si | 详情 | 详情 | |
| (XIII) | 56265 | (3S,4S)-4-amino-3,4-dihydro-2H-chromen-3-ol | C9H11NO2 | 详情 | 详情 | |
| (XIV) | 65092 | (4R)-3-((2S,4R)-4-benzyl-2-{[tert-butyl(dimethyl)silyl]oxy}-5-{[(3S,4S)-3-hydroxy-3,4-dihydro-2H-chromen-4-yl]amino}-5-oxopentanoyl)-N-[(3,5-dimethyl-4-isothiazolyl)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide | C39H54N4O6S2Si | 详情 | 详情 |
Extended Information