N-[1-(phenylmethyl)-4-piperidinyl]acetamide -Drug Synthesis Database

【结构式】

【分子编号】64809

【品名】N-[1-(phenylmethyl)-4-piperidinyl]acetamide

【CA登记号】

【分子式】C₁₄H₂₀N₂O

【分子量】232.32568

【元素组成】C 72.38% H 8.68% N 12.06% O 6.89%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

Acylation of 4-amino-1-benzylpiperidine (I) with acetyl chloride provides the amide (II). Subsequent debenzylation of (II) by transfer hydrogenation with ammonium formate in the presence of Pd/C yields the piperidine (III), which is finally acylated with 4-fluorobenzenesulfonyl chloride (IV) to give the corresponding sulfonamide.

参考文献中间体

合成目标

【1】 Manetti, D.; Martini, E.; Ghelardini, C.; Dei, S.; Galeotti, N.; Guandalini, L.; Romanelli, M.N.; Scapecchi, S.; Teodori, E.; Bartolini, A.; Gualtieri, F.; 4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs. Bioorg Med Chem Lett 2003, 13, 14, 2303.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	34808	1-Benzyl-4-piperidinylamine; 1-Benzyl-4-piperidinamine; 4-Amino-1-benzylpiperidine	50541-93-0	C₁₂H₁₈N₂	详情	详情
(II)	64809	N-[1-(phenylmethyl)-4-piperidinyl]acetamide		C₁₄H₂₀N₂O	详情	详情
(III)	64810	N-(4-piperidinyl)acetamide		C₇H₁₄N₂O	详情	详情
(IV)	12292	4-Fluorobenzenesulfonyl chloride	349-88-2	C₆H₄ClFO₂S	详情	详情

Extended Information