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【结 构 式】 
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【分子编号】64755 【品名】 【CA登记号】 |
【 分 子 式 】C50H75NO10 【 分 子 量 】850.14624 【元素组成】C 70.64% H 8.89% N 1.65% O 18.82% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XXIX)Acylation of alcohol (XXVIII) with trichloroacetyl isocyanate, followed by alkaline hydrolysis of the trichloroacetyl group leads to the carbamate (XXIX). The methyl acetal function of (XXIX) is then hydrolyzed with aqueous AcOH, and the resultant lactol is further oxidized to the corresponding lactone (XXX) by means of the Dess-Martin periodinane reagent. Finally, removal of the p-methoxybenzyl protecting groups of (XXX) in the presence of DDQ provides the target compound.
| 【1】 Choy, N.; Shin, Y.; Nguyen, P.Q.; Curran, D.P.; Balachandran, R.; Madiraju, C.; Day, B.W.; Simplified discodermolide analogues: Synthesis and biological evaluation of 4-epi-7-dehydroxy-14,16-didemethyl-(+)-discodermolides as microtubule-stabilizing agents. J Med Chem 2003, 46, 14, 2846. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XXVIII) | 64754 | 19-(3,5-dimethyl-6-(methyloxy)-4-{[(methyloxy)methyl]oxy}tetrahydro-2H-pyran-2-yl)-5,7,13,15-tetramethyl-8,14-bis({[4-(methyloxy)phenyl]methyl}oxy)-1,3,11,16-nonadecatetraen-6-ol | C49H74O9 | 详情 | 详情 | |
| (XXIX) | 64755 | C50H75NO10 | 详情 | 详情 | ||
| (XXX) | 64756 | 14-(3,5-dimethyl-4-{[(methyloxy)methyl]oxy}-6-oxotetrahydro-2H-pyran-2-yl)-2,8,10-trimethyl-3,9-bis({[4-(methyloxy)phenyl]methyl}oxy)-1-(1-methyl-2,4-pentadienyl)-6,11-tetradecadienyl carbamate | C49H71NO10 | 详情 | 详情 |
Extended Information