【结 构 式】 |
【分子编号】64752 【品名】[6-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-5,7-dimethyl-4-({[4-(methyloxy)phenyl]methyl}oxy)-8,10-undecadienyl](triphenyl)phosphonium iodide 【CA登记号】 |
【 分 子 式 】C45H60IO3PSi 【 分 子 量 】834.933332 【元素组成】C 64.74% H 7.24% I 15.2% O 5.75% P 3.71% Si 3.36% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(XXVI)Wittig condensation of aldehyde (XXV) with the phosphonium salt (XXVI) produces the olefin adduct (XXVII). The O-silyl protecting group of (XXVII) is then removed by treatment with tetrabutylammonium fluoride to afford alcohol (XXVIII).
【1】 Choy, N.; Shin, Y.; Nguyen, P.Q.; Curran, D.P.; Balachandran, R.; Madiraju, C.; Day, B.W.; Simplified discodermolide analogues: Synthesis and biological evaluation of 4-epi-7-dehydroxy-14,16-didemethyl-(+)-discodermolides as microtubule-stabilizing agents. J Med Chem 2003, 46, 14, 2846. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(XXV) | 64751 | 8-(3,5-dimethyl-6-(methyloxy)-4-{[(methyloxy)methyl]oxy}tetrahydro-2H-pyran-2-yl)-2,4-dimethyl-3-({[4-(methyloxy)phenyl]methyl}oxy)-5-octenal | C28H44O7 | 详情 | 详情 | |
(XXVI) | 64752 | [6-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-5,7-dimethyl-4-({[4-(methyloxy)phenyl]methyl}oxy)-8,10-undecadienyl](triphenyl)phosphonium iodide | C45H60IO3PSi | 详情 | 详情 | |
(XXVII) | 64753 | (1,1-dimethylethyl)(dimethyl)silyl 14-(3,5-dimethyl-6-(methyloxy)-4-{[(methyloxy)methyl]oxy}tetrahydro-2H-pyran-2-yl)-2,8,10-trimethyl-3,9-bis({[4-(methyloxy)phenyl]methyl}oxy)-1-(1-methyl-2,4-pentadienyl)-6,11-tetradecadienyl ether; (1,1-dimethylethyl){[14-(3,5-dimethyl-6-(methyloxy)-4-{[(methyloxy)methyl]oxy}tetrahydro-2H-pyran-2-yl)-2,8,10-trimethyl-3,9-bis({[4-(methyloxy)phenyl]methyl}oxy)-1-(1-methyl-2,4-pentadienyl)-6,11-tetradecadienyl]oxy}dimethylsilane | C55H88O9Si | 详情 | 详情 | |
(XXVIII) | 64754 | 19-(3,5-dimethyl-6-(methyloxy)-4-{[(methyloxy)methyl]oxy}tetrahydro-2H-pyran-2-yl)-5,7,13,15-tetramethyl-8,14-bis({[4-(methyloxy)phenyl]methyl}oxy)-1,3,11,16-nonadecatetraen-6-ol | C49H74O9 | 详情 | 详情 |
Extended Information