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【结 构 式】 
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【分子编号】64557 【品名】(4-methoxy-2-nitrophenyl)(3,4,5-trimethoxyphenyl)methanone 【CA登记号】 |
【 分 子 式 】C17H17NO7 【 分 子 量 】347.32452 【元素组成】C 58.79% H 4.93% N 4.03% O 32.25% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(V)Treatment of 3,4,5-trimethoxybromobenzene (I) with Mg in THF produces the corresponding Grignard reagent (II), which is condensed with 4-methoxy-2-nitrobenzaldehyde (III) to furnish the benzhydrol derivative (IV). Oxidation of benzhydrol (IV) by means of pyridinium dichromate leads to benzophenone (V). The nitro group of (V) is then reduced to the corresponding amine employing iron powder in AcOH.
| 【1】 Liou, J.-P.; et al.; Synthesis and structure-activity relationship of 2-aminobenzophenone derivatives as antimitotic agents. J Med Chem 2002, 45, 12, 2556. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 64554 | 4-bromo-2,6-dimethoxyphenyl methyl ether; 5-bromo-1,2,3-trimethoxybenzene | C9H11BrO3 | 详情 | 详情 | |
| (II) | 32378 | bromo(3,4,5-trimethoxyphenyl)magnesium | C9H11BrMgO3 | 详情 | 详情 | |
| (III) | 64555 | 4-methoxy-2-nitrobenzaldehyde | C8H7NO4 | 详情 | 详情 | |
| (IV) | 64556 | (4-methoxy-2-nitrophenyl)(3,4,5-trimethoxyphenyl)methanol | C17H19NO7 | 详情 | 详情 | |
| (V) | 64557 | (4-methoxy-2-nitrophenyl)(3,4,5-trimethoxyphenyl)methanone | C17H17NO7 | 详情 | 详情 |
Extended Information