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【结 构 式】

【分子编号】64218

【品名】tert-butyl 2-(2-aminoethyl)benzylcarbamate

【CA登记号】

【 分 子 式 】C14H22N2O2

【 分 子 量 】250.34096

【元素组成】C 67.17% H 8.86% N 11.19% O 12.78%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XXVI)

In a related synthesis of (XXV) starting from the mono-protected diamine (XXVI), alkylation with ethyl 3-bromopropionate (XXVII) leads to amino ester (XXVIII), which is further protected as the di-Boc derivative (XXIX). Reduction of ester (XXIX) employing LiAlH4 furnishes alcohol (XXIV), which is further oxidized to aldehyde (XXV) under Swern conditions.

1 Nantermet, P.G.; Barrow, J.C.; Newton, C.L.; Pellicore, J.M.; Young, M.; Lewis, S.D.; Lucas, B.J.; Krueger, J.A.; McMasters, D.R.; Youwei, Y.; Kuo, L.C.; Vacca, J.P.; Selnick, H.G.; Design and synthesis of potent and selective macrocyclic thrombin inhibitors. 225th ACS Natl Meet (March 23 2003, New Orleans) 2003, Abst MEDI 168.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(XXIV) 64216 tert-butyl 2-{[(tert-butoxycarbonyl)amino]methyl}phenethyl(3-hydroxypropyl)carbamate C22H36N2O5 详情 详情
(XXV) 64217 tert-butyl 2-{[(tert-butoxycarbonyl)amino]methyl}phenethyl(3-oxopropyl)carbamate C22H34N2O5 详情 详情
(XXVI) 64218 tert-butyl 2-(2-aminoethyl)benzylcarbamate C14H22N2O2 详情 详情
(XXVII) 29132 ethyl 3-bromopropanoate 539-74-2 C5H9BrO2 详情 详情
(XXVIII) 64219 ethyl 3-[(2-{[(tert-butoxycarbonyl)amino]methyl}phenethyl)amino]propanoate C19H30N2O4 详情 详情
(XXIX) 64220 ethyl 3-[(tert-butoxycarbonyl)(2-{[(tert-butoxycarbonyl)amino]methyl}phenethyl)amino]propanoate C24H38N2O6 详情 详情
Extended Information