(Z)-11-octadecenoic acid -Drug Synthesis Database

【结构式】

【分子编号】64192

【品名】(Z)-11-octadecenoic acid

【CA登记号】

【分子式】C₁₈H₃₄O₂

【分子量】282.46676

【元素组成】C 76.54% H 12.13% O 11.33%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(LXI)

Amine (LX) was acylated with cis-vaccenic acid (LXI) to produce amide (LXII). This was desilylated by means of HF yielding alcohol (XXXIX), which was finally converted to the title compound using the same sequence as in Scheme 27814501f.

参考文献中间体

合成目标

【1】 Kobayashi, S.; Kawata, T.; Christ, W.J.; Rossignol, D.P. (Eisai Co., Ltd.); Substd. liposaccharides useful in the treatment and prevention of endotoxemia. US 5750664; WO 9639411 .

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(XXXIX)	64171	allyl (2R,3S,4R,5R)-2-[({(2R,3R,4R,5S,6R)-5-{[bis(allyloxy)phosphoryl]oxy}-4-{[(3R)-3-methoxydecyl]oxy}-6-(methoxymethyl)-3-[(Z)-11-octadecenoylamino]tetrahydro-2H-pyran-2-yl}oxy)methyl]-4-(decyloxy)-6-hydroxy-5-[(3-oxotetradecanoyl)amino]tetrahydro-2H-pyran-3-yl carbonate	C₇₆H₁₃₇N₂O₁₈P	详情	详情
(LX)	64191	allyl (2R,3S,4R,5R)-2-({[(2R,3R,4R,5S,6R)-3-amino-5-{[bis(allyloxy)phosphoryl]oxy}-4-{[(3R)-3-methoxydecyl]oxy}-6-(methoxymethyl)tetrahydro-2H-pyran-2-yl]oxy}methyl)-6-{[tert-butyl(dimethyl)silyl]oxy}-4-(decyloxy)-5-[(3-oxotetradecanoyl)amino]tetrahydro-2H-pyran-3-yl carbonate	C₆₄H₁₁₉N₂O₁₇PSi	详情	详情
(LXI)	64192	(Z)-11-octadecenoic acid	C₁₈H₃₄O₂	详情	详情
(LXIII)	64193	allyl (2R,3S,4R,5R)-2-[({(2R,3R,4R,5S,6R)-5-{[bis(allyloxy)phosphoryl]oxy}-4-{[(3R)-3-methoxydecyl]oxy}-6-(methoxymethyl)-3-[(Z)-11-octadecenoylamino]tetrahydro-2H-pyran-2-yl}oxy)methyl]-6-{[tert-butyl(dimethyl)silyl]oxy}-4-(decyloxy)-5-[(3-oxotetradecanoyl)amino]tetrahydro-2H-pyran-3-yl carbonate	C₈₂H₁₅₁N₂O₁₈PSi	详情	详情

Extended Information