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【结 构 式】 
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【分子编号】64181 【品名】2,2,2-trichloroethyl (2S,3R,4R,5S,6R)-5-{[bis(allyloxy)phosphoryl]oxy}-2-{[tert-butyl(dimethyl)silyl]oxy}-4-{[(3R)-3-methoxydecyl]oxy}-6-(methoxymethyl)tetrahydro-2H-pyran-3-ylcarbamate 【CA登记号】 |
【 分 子 式 】C33H61Cl3NO11PSi 【 分 子 量 】813.264842 【元素组成】C 48.74% H 7.56% Cl 13.08% N 1.72% O 21.64% P 3.81% Si 3.45% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(L)Azido sugar (XLVIII) was reduced to the corresponding amine (XLIX) employing the in situ generated tin tris(benzenthiolate) triethylamine complex. Amine (XLIX) was then protected as the trichloethyl carbamate (L) by treatment with Troc-chloride and pyridine. After desilylation of (L) with HF, the resultant alcohol was activated as the trichloroacetimidate (XXXIV) as in Scheme 27814501e.
| 【1】 Kobayashi, S.; Kawata, T.; Christ, W.J.; Rossignol, D.P. (Eisai Co., Ltd.); Substd. liposaccharides useful in the treatment and prevention of endotoxemia. US 5750664; WO 9639411 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XXXIV) | 64166 | (3R,4R,5S,6R)-5-{[bis(allyloxy)phosphoryl]oxy}-4-{[(3R)-3-methoxydecyl]oxy}-6-(methoxymethyl)-3-{[(2,2,2-trichloroethoxy)carbonyl]amino}tetrahydro-2H-pyran-2-yl 2,2,2-trichloroethanimidoate | C29H47Cl6N2O11P | 详情 | 详情 | |
| (XLVIII) | 64179 | diallyl (2R,3S,4R,5R,6S)-5-azido-6-{[tert-butyl(dimethyl)silyl]oxy}-4-{[(3R)-3-methoxydecyl]oxy}-2-(methoxymethyl)tetrahydro-2H-pyran-3-yl phosphate | C30H58N3O9PSi | 详情 | 详情 | |
| (XLIX) | 64180 | diallyl (2R,3S,4R,5R,6S)-5-amino-6-{[tert-butyl(dimethyl)silyl]oxy}-4-{[(3R)-3-methoxydecyl]oxy}-2-(methoxymethyl)tetrahydro-2H-pyran-3-yl phosphate | C30H60NO9PSi | 详情 | 详情 | |
| (L) | 64181 | 2,2,2-trichloroethyl (2S,3R,4R,5S,6R)-5-{[bis(allyloxy)phosphoryl]oxy}-2-{[tert-butyl(dimethyl)silyl]oxy}-4-{[(3R)-3-methoxydecyl]oxy}-6-(methoxymethyl)tetrahydro-2H-pyran-3-ylcarbamate | C33H61Cl3NO11PSi | 详情 | 详情 |
Extended Information