2-(acetyloxy)-1-[(acetyloxy)methyl]ethyl acetate -Drug Synthesis Database

【结构式】

【分子编号】64100

【品名】2-(acetyloxy)-1-[(acetyloxy)methyl]ethyl acetate

【CA登记号】

【分子式】C₉H₁₄O₆

【分子量】218.20656

【元素组成】C 49.54% H 6.47% O 43.99%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The condensation of diacetyl guanine (I) with 1,3-diacetoxy-2-(acetoxymethoxy)propane (II) by means of TsOH in hot DMF gives the target intermediate, N2-acetyl-9-[2-acetoxy-1-(acetoxymethyl)ethoxymethyl]guanine (III). (see Synthline Scheme no. 11147104a, intermediate no. (XV)).

参考文献中间体

合成目标

【1】 Kumar, Y.; Khanduri, C.H.; Ray, P.C.; Babu, J.S. (Ranbaxy Laboratories Ltd.); A process for the preparation of ganciclovir intermediate N2-acetyl-9-(1,3-diacetoxy-2-propoxymethyl)guanine. WO 0333498 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	29161	N-(9-acetyl-6-oxo-6,9-dihydro-1H-purin-2-yl)acetamide; N2,9-Diacetylguanine	3056-33-5	C₉H₉N₅O₃	详情	详情
(II)	64100	2-(acetyloxy)-1-[(acetyloxy)methyl]ethyl acetate		C₉H₁₄O₆	详情	详情
(III)	29170	2-[[2-(acetamido)-6-oxo-1,6-dihydro-9H-purin-9-yl]methoxy]-3-(acetoxy)propyl acetate		C₁₅H₁₉N₅O₇	详情	详情

Extended Information