【结 构 式】 |
【分子编号】64056 【品名】4'-[(3-{4-[2-amino-3-(1,3-thiazol-4-yl)propanoyl]-1,4-diazepan-1-yl}propyl)oxy][1,1'-biphenyl]-4-carbonitrile 【CA登记号】 |
【 分 子 式 】C27H31N5O2S 【 分 子 量 】489.64164 【元素组成】C 66.23% H 6.38% N 14.3% O 6.54% S 6.55% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(IX)Acidic cleavage of the N-Boc group of (VIII) furnishes amine (IX). Finally, acylation of (IX) with 2-furoyl chloride (X) leads to the title compound. (1,2)
【1】 Curtis, M.P.; Dwight, W.; Fox, G.B.; Esbenshade, T.A.; Pan, J-B.; Bennani, Y.L.; Hancock, A.A.; Faghih, R.; A-320436: Potent human non-imidazole histamine H3 receptor antagonist. 225th ACS Natl Meet (March 23 2003, New Orleans) 2003, Abst MEDI 240. |
【2】 Black, L.A.; Faghih, R.; Bennani, Y.L.; Liu, H.; Zhang, H.Q.; Dwight, W.J.; Gentles, R.G.; Phelan, K.M.; Vasudevan, A. (Abbott Laboratories Inc.); Cyclic and bicyclic diamino histamine-3 receptor antagonists. WO 0166534 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(VIII) | 64055 | 1,1-dimethylethyl 2-(4-{3-[(4'-cyano[1,1'-biphenyl]-4-yl)oxy]propyl}-1,4-diazepan-1-yl)-2-oxo-1-(1,3-thiazol-4-ylmethyl)ethylcarbamate | C32H39N5O4S | 详情 | 详情 | |
(IX) | 64056 | 4'-[(3-{4-[2-amino-3-(1,3-thiazol-4-yl)propanoyl]-1,4-diazepan-1-yl}propyl)oxy][1,1'-biphenyl]-4-carbonitrile | C27H31N5O2S | 详情 | 详情 | |
(X) | 26093 | 2-Furoyl chloride | 527-69-5 | C5H3ClO2 | 详情 | 详情 |
Extended Information