【结 构 式】 |
【分子编号】63967 【品名】methyl 3-{[(3-chlorophenyl)sulfonyl]amino}-2-thiophenecarboxylate 【CA登记号】 |
【 分 子 式 】C12H10ClNO4S2 【 分 子 量 】331.80044 【元素组成】C 43.44% H 3.04% Cl 10.68% N 4.22% O 19.29% S 19.33% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(III)Methyl 3-aminothiophene-2-carboxylate (I) is acylated by 3-chlorobenzenesulfonyl chloride (II) to produce sulfonamide (III). After alkaline hydrolysis of the methyl ester group of (III), the resultant carboxylic acid (IV) is chlorinated by means of oxalyl chloride to furnish acid chloride (V). Finally, coupling of acid chloride (V) with 6-amino-2-methylbenzothiazole (VI) yields the title carboxamide.
【1】 Weinstock, J.; Franz, R.G. (GlaxoSmithKline Inc.); Phosphate transport inhibitors. WO 0228353 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 27686 | 3-amino-2-thiophenecarboxylic acid methyl ester; methyl 3-amino-2-thiophenecarboxylate | 22288-78-4 | C6H7NO2S | 详情 | 详情 |
(II) | 63966 | 3-chlorobenzenesulfonyl chloride | C6H4Cl2O2S | 详情 | 详情 | |
(III) | 63967 | methyl 3-{[(3-chlorophenyl)sulfonyl]amino}-2-thiophenecarboxylate | C12H10ClNO4S2 | 详情 | 详情 | |
(IV) | 63968 | 3-{[(3-chlorophenyl)sulfonyl]amino}-2-thiophenecarboxylic acid | C11H8ClNO4S2 | 详情 | 详情 | |
(V) | 63969 | 3-{[(3-chlorophenyl)sulfonyl]amino}-2-thiophenecarbonyl chloride | C11H7Cl2NO3S2 | 详情 | 详情 | |
(VI) | 63970 | 2-methyl-1,3-benzothiazol-6-amine; 2-methyl-1,3-benzothiazol-6-ylamine | C8H8N2S | 详情 | 详情 |
Extended Information