2-(chloromethoxy)ethyl acetate -Drug Synthesis Database

【结构式】

【分子编号】63950

【品名】2-(chloromethoxy)ethyl acetate

【CA登记号】

【分子式】C₅H₉ClO₃

【分子量】152.57736

【元素组成】C 39.36% H 5.95% Cl 23.24% O 31.46%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

PMEA was prepared by a straightforward route from readily available 2-acetoxyethoxymethyl chloride (I). The key intermediate, diethyl 2-bromoethylmethoxyphosphonate (IV), was coupled with adenine (V) in the presence of sodium hydride, followed by hydrolysis to afford PMEA.

参考文献中间体

合成目标

【1】 Hwang, J.-T.; Choi, J.-R.; Novel phosphonate nucleosides as antiviral agents. Drugs Fut 2004, 29, 2, 163.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	63950	2-(chloromethoxy)ethyl acetate		C₅H₉ClO₃	详情	详情
(II)	39883	2-[(diethoxyphosphoryl)methoxy]ethyl acetate		C₉H₁₉O₆P	详情	详情
(III)	39884	diethyl (2-hydroxyethoxy)methylphosphonate		C₇H₁₇O₅P	详情	详情
(IV)	39886	diethyl (2-bromoethoxy)methylphosphonate		C₇H₁₆BrO₄P	详情	详情
(V)	10343	9H-Purin-6-amine; 9H-Purin-6-ylamine; Adenine	73-24-5	C₅H₅N₅	详情	详情
(VI)	39673	diethyl [2-(6-amino-9H-purin-9-yl)ethoxy]methylphosphonate		C₁₂H₂₀N₅O₄P	详情	详情

Extended Information