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【结 构 式】 
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【分子编号】63791 【品名】4-[(3-pyridinylcarbonyl)amino]butanoic acid 【CA登记号】 |
【 分 子 式 】C10H12N2O3 【 分 子 量 】208.21696 【元素组成】C 57.69% H 5.81% N 13.45% O 23.05% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)Nicotinic acid azide (I) is mixed with a solution of gamma-aminobutyric acid (II) in 1 N NaOH (pH 8-9). The mixture is stirred for 24 hours, evaporated and the residue is washed with methanol. The resultant sodium salt of nicotinoyl-gamma-aminobutyric acid is then dried. It can be further converted to nicotinoyl-gamma-aminobutyric acid (III) by dissolving in a minimum amount of water and adjusting pH to 3.5.
| 【1】 Kopelevich, V.M.; Trubnikov, V.I.; Shmvilovich, L.M.; et al. (USSR Res. Inst. Vitamins); Process for the preparation of N-nicotinoyl-gamma-aminoaliphatic acids or its esters. SU 325232 . |
| 【2】 Rejholec, V.; PIKAMILONE. Drugs Fut 1990, 15, 2, 133. |
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