3-nitro-2-pyridinol -Drug Synthesis Database

【结构式】

【分子编号】63725

【品名】3-nitro-2-pyridinol

【CA登记号】

【分子式】C₅H₄N₂O₃

【分子量】140.09844

【元素组成】C 42.87% H 2.88% N 20% O 34.26%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

Catalytic hydrogenation of 2-hydroxy-3-nitropyridine (I) in the presence of Pd/C affords 3-amino-2-hydroxypyridine (II). This is then acylated by 5-methylisoxazole-3-carbonyl chloride (III) to furnish the corresponding amide (IV). (1)

参考文献中间体

合成目标

【1】 Dragovich, P.S.; Prins, T.J.; Zhou, R.; Johnson, T.O. Jr. (Agouron Pharmaceuticals, Inc.); Antipicornaviral cpds. and compsns., their pharmaceutical uses, and material for their synthesis. JP 2003515591; US 2001047006; US 6514997; WO 0140189 .

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	63725	3-nitro-2-pyridinol	C₅H₄N₂O₃	详情	详情
(II)	63726	3-amino-2-pyridinol	C₅H₆N₂O	详情	详情
(III)	32107	5-methyl-3-isoxazolecarbonyl chloride	C₅H₄ClNO₂	详情	详情
(IV)	63727	N-(2-hydroxy-3-pyridinyl)-5-methyl-3-isoxazolecarboxamide	C₁₀H₉N₃O₃	详情	详情

Extended Information