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【结 构 式】 
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【分子编号】63696 【品名】N~1~-methyl-N~4~-(phenylmethylidene)-1,4-cyclohexanediamine 【CA登记号】 |
【 分 子 式 】C14H20N2 【 分 子 量 】216.32628 【元素组成】C 77.73% H 9.32% N 12.95% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)1,4-Diaminocyclohexane (I) is converted into the mono-carbamate (II) employing di-tert-butyl dicarbonate in cold THF. Subsequent reduction of carbamate (II) by means of LiAlH4 leads to the N-methyl amine (III). After blocking the primary amino group of (III) as the corresponding benzaldimine (IV), treatment with di-tert-butyl dicarbonate gives rise to the mono-protected diamine (V). (1,2)
| 【1】 Baxter, A.D.; Boyd, E.A.; Price, S.; Guicherit, O.M.; Porter, J.; Rubin, L.E. (Curis, Inc.); Small organic molecule regulators of cell proliferation. US 6613798; US 6683108; WO 0174344 . |
| 【2】 Baxter, A.D.; Boyd, E.A.; Price, S.; Guicherit, O.M.; Porter, J.; Rubin, L.; Stibbard, J.H.A. (Curis, Inc.); Small organic molecule regulators of cell proliferation. US 2002198236; WO 0327234 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 43407 | 4-aminocyclohexylamine; 1,4-cyclohexanediamine | 3114-70-3 | C6H14N2 | 详情 | 详情 |
| (II) | 43408 | tert-butyl 4-aminocyclohexylcarbamate | C11H22N2O2 | 详情 | 详情 | |
| (III) | 63695 | N~1~-methyl-1,4-cyclohexanediamine | C7H16N2 | 详情 | 详情 | |
| (IV) | 63696 | N~1~-methyl-N~4~-(phenylmethylidene)-1,4-cyclohexanediamine | C14H20N2 | 详情 | 详情 | |
| (V) | 63697 | 1,1-dimethylethyl 4-aminocyclohexyl(methyl)carbamate | C12H24N2O2 | 详情 | 详情 |
Extended Information