N-[1-butyl-4-(3-hydroxyphenyl)-2-oxo-1,2-dihydro[1,8]naphthyridin-3-yl]-N'-(2,6-diisopropylphenyl)urea -Drug Synthesis Database

【结构式】

【分子编号】63691

【品名】N-[1-butyl-4-(3-hydroxyphenyl)-2-oxo-1,2-dihydro[1,8]naphthyridin-3-yl]-N'-(2,6-diisopropylphenyl)urea

【CA登记号】

【分子式】C₃₁H₃₆N₄O₃

【分子量】512.652

【元素组成】C 72.63% H 7.08% N 10.93% O 9.36%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VIII)

Cleavage of the methyl ether function of (VII) by means of BBr3 in cold CH2Cl2 leads to phenol (VIII). This is finally alkylated by 3-picolyl chloride (IX) in the presence of K2CO3/NaI to furnish the title compound.

参考文献中间体

合成目标

【1】 Muraoka, M.; Ioriya, K.; Ohashi, N.; Yagi, H. (Sumitomo Pharmaceuticals Co., Ltd.); Novel naphthyridine derivs.. EP 0947515; JP 1998212288; WO 9823615 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(VII)	63690	N-[1-butyl-4-(3-methoxyphenyl)-2-oxo-1,2-dihydro[1,8]naphthyridin-3-yl]-N'-(2,6-diisopropylphenyl)urea		C₃₂H₃₈N₄O₃	详情	详情
(VIII)	63691	N-[1-butyl-4-(3-hydroxyphenyl)-2-oxo-1,2-dihydro[1,8]naphthyridin-3-yl]-N'-(2,6-diisopropylphenyl)urea		C₃₁H₃₆N₄O₃	详情	详情
(IX)	15793	3-(Chloromethyl)pyridine	3099-31-8	C₆H₆ClN	详情	详情

Extended Information