benzyl 6-chloro-8-[5-oxo-4-(1-phenethyl-4-piperidinyl)-4,5-dihydro-1,3,4-oxadiazol-2-yl]-2,3-dihydro-1,4-benzodioxin-5-ylcarbamate -Drug Synthesis Database

【结构式】

【分子编号】63660

【品名】benzyl 6-chloro-8-[5-oxo-4-(1-phenethyl-4-piperidinyl)-4,5-dihydro-1,3,4-oxadiazol-2-yl]-2,3-dihydro-1,4-benzodioxin-5-ylcarbamate

【CA登记号】

【分子式】C₃₁H₃₁ClN₄O₆

【分子量】591.0632

【元素组成】C 63% H 5.29% Cl 6% N 9.48% O 16.24%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(X)

Piperidine (VIII) is alkylated with phenethyl bromide (IX) to furnish (X). The benzyloxycarbonyl protecting group of (X) is finally removed by treatment with HBr in AcOH to provide the title compound.

参考文献中间体

合成目标

【1】 Jegham, S.; Lochead, A.; Galli, F.; Nedelec, A.; Solignac, A.; De Cruz, L. (Sanofi-Synthélabo); 5-Phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol-2(3H)-one derivs. for use as 5-HT4 or H3 receptor ligands. EP 0863897; FR 2741069; FR 2741070; JP 2000500125; US 5929089; WO 9717345 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(VIII)	63659	benzyl 6-chloro-8-[5-oxo-4-(4-piperidinyl)-4,5-dihydro-1,3,4-oxadiazol-2-yl]-2,3-dihydro-1,4-benzodioxin-5-ylcarbamate		C₂₃H₂₃ClN₄O₆	详情	详情
(IX)	20730	1-(2-bromoethyl)benzene；1-Bromo-2-phenylethane;(2-Bromoethyl)benzene;Phenethyl bromide	103-63-9	C₈H₉Br	详情	详情
(X)	63660	benzyl 6-chloro-8-[5-oxo-4-(1-phenethyl-4-piperidinyl)-4,5-dihydro-1,3,4-oxadiazol-2-yl]-2,3-dihydro-1,4-benzodioxin-5-ylcarbamate		C₃₁H₃₁ClN₄O₆	详情	详情

Extended Information