• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】63547

【品名】N,N-dimethyl-4-[6-(tributylstannyl)imidazo[1,2-a]pyridin-2-yl]aniline; N,N-dimethyl-N-{4-[6-(tributylstannyl)imidazo[1,2-a]pyridin-2-yl]phenyl}amine

【CA登记号】

【 分 子 式 】C27H41N3Sn

【 分 子 量 】526.35276

【元素组成】C 61.61% H 7.85% N 7.98% Sn 22.55%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

Condensation between 2-bromo-4'-(dimethylamino)acetophenone (I) and 2-amino-5-bromopyridine (II) gives rise to the imidazopyridine (III). Subsequent palladium-catalyzed stannylation of (III) affords the tributyltin derivative (IV). The target radio-iodinated compound is then obtained by iododstannylation of (IV) with [125I] iodide in the presence of H2O2 (1,2)

1 Zhuang, Z.-P.; Kung, M.-P.; Wilson, A.; Lee, C.-W.; Plossl, K.; Hou, C.; Holtzman, D.M.; Kung, H.F.; Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain. J Med Chem 2003, 46, 2, 237.
2 Kung, H.; Kung, M.-P.; Zhuang, Z.-P. (University of Pennsylvania); Amyloid plaque aggregation inhibitors and diagnostic imaging agents. CA 2444214; EP 1381604; US 2003059369; WO 0285903 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 63545 2-bromo-1-[4-(dimethylamino)phenyl]-1-ethanone C10H12BrNO 详情 详情
(II) 12123 5-Bromo-2-pyridinylamine; 5-Bromo-2-pyridinamine; 2-Amino-5-bromopyridine 1072-97-5 C5H5BrN2 详情 详情
(III) 63546 4-(6-bromoimidazo[1,2-a]pyridin-2-yl)-N,N-dimethylaniline; N-[4-(6-bromoimidazo[1,2-a]pyridin-2-yl)phenyl]-N,N-dimethylamine C15H14BrN3 详情 详情
(IV) 63547 N,N-dimethyl-4-[6-(tributylstannyl)imidazo[1,2-a]pyridin-2-yl]aniline; N,N-dimethyl-N-{4-[6-(tributylstannyl)imidazo[1,2-a]pyridin-2-yl]phenyl}amine C27H41N3Sn 详情 详情
Extended Information