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【结 构 式】

【分子编号】63517

【品名】2-aminododecanoic acid

【CA登记号】

【 分 子 式 】C12H25NO2

【 分 子 量 】215.33604

【元素组成】C 66.93% H 11.7% N 6.5% O 14.86%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

Alkylation of diethyl acetamidomalonate (I) with 1-bromodecane (II) affords malonate (III). Subsequent hydrolysis and decarboxylation of (III) under acidic conditions leads to 2-aminododecanoic acid (IV). This is then protected as the N-Boc derivative (V) upon treatment with Boc2O and NaOH

1 Blanchfield, J.T.; Dutton, J.L.; Hogg, R.C.; Gallagher, O.P.; Craik, D.J.; Jones, A.; Adams, D.J.; Lewis, R.J..; Alewood, P.F.; Toth, I.; Synthesis, structure elucidation, in vitro biological activity, toxicity, and caco-2 cell permeability of lipophilic analogues of alpha-conotoxin MII. J Med Chem 2003, 46, 7, 1266.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 16710 Diethyl 2-(acetamido)malonate; Diethyl acetamidomalonate 1068-90-2 C9H15NO5 详情 详情
(II) 58570 1-Bromodecane; 1-Decyl bromide; Decyl bromide; n-decyl bromide 112-29-8 C10H21Br 详情 详情
(III) 63516 diethyl 2-(acetylamino)-2-decylpropanedioate C19H35NO5 详情 详情
(IV) 63517 2-aminododecanoic acid C12H25NO2 详情 详情
(V) 63518 2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)dodecanoic acid C17H33NO4 详情 详情
Extended Information