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【结 构 式】 
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【分子编号】63517 【品名】2-aminododecanoic acid 【CA登记号】 |
【 分 子 式 】C12H25NO2 【 分 子 量 】215.33604 【元素组成】C 66.93% H 11.7% N 6.5% O 14.86% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)Alkylation of diethyl acetamidomalonate (I) with 1-bromodecane (II) affords malonate (III). Subsequent hydrolysis and decarboxylation of (III) under acidic conditions leads to 2-aminododecanoic acid (IV). This is then protected as the N-Boc derivative (V) upon treatment with Boc2O and NaOH
| 【1】 Blanchfield, J.T.; Dutton, J.L.; Hogg, R.C.; Gallagher, O.P.; Craik, D.J.; Jones, A.; Adams, D.J.; Lewis, R.J..; Alewood, P.F.; Toth, I.; Synthesis, structure elucidation, in vitro biological activity, toxicity, and caco-2 cell permeability of lipophilic analogues of alpha-conotoxin MII. J Med Chem 2003, 46, 7, 1266. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 16710 | Diethyl 2-(acetamido)malonate; Diethyl acetamidomalonate | 1068-90-2 | C9H15NO5 | 详情 | 详情 |
| (II) | 58570 | 1-Bromodecane; 1-Decyl bromide; Decyl bromide; n-decyl bromide | 112-29-8 | C10H21Br | 详情 | 详情 |
| (III) | 63516 | diethyl 2-(acetylamino)-2-decylpropanedioate | C19H35NO5 | 详情 | 详情 | |
| (IV) | 63517 | 2-aminododecanoic acid | C12H25NO2 | 详情 | 详情 | |
| (V) | 63518 | 2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)dodecanoic acid | C17H33NO4 | 详情 | 详情 |
Extended Information