6-amino-3-methyl-5-nitroso-1-phenyl-2,4(1H,3H)-pyrimidinedione -Drug Synthesis Database

【结构式】

【分子编号】63475

【品名】6-amino-3-methyl-5-nitroso-1-phenyl-2,4(1H,3H)-pyrimidinedione

【CA登记号】

【分子式】C₁₁H₁₀N₄O₃

【分子量】246.22556

【元素组成】C 53.66% H 4.09% N 22.75% O 19.49%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

Nitrosation of pyrimidinedione (I) with NaNO2/HCl affords (II), which is further reduced to the diaminopyrimidine (III) by catalytic hydrogenation over Pd/C. Subsequent coupling of (III) with 2,6-di-tert-butyl-4-hydroxycinnamic acid (IV) employing DPP-Cl furnishes the title amide

参考文献中间体

合成目标

【1】 Isobe, Y.; Tobe, M.; Inoue, Y.; Goto, Y.; Obara, F.; Isobe, M.; Hayashi, H.; Inhibitory activities of novel pyrimidine derivatives on the contact hypersensitivity reaction. Chem Pharm Bull 2003, 51, 3, 309.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	44183	6-amino-3-methyl-1-phenyl-2,4(1H,3H)-pyrimidinedione		C₁₁H₁₁N₃O₂	详情	详情
(II)	63475	6-amino-3-methyl-5-nitroso-1-phenyl-2,4(1H,3H)-pyrimidinedione		C₁₁H₁₀N₄O₃	详情	详情
(III)	44185	5,6-diamino-3-methyl-1-phenyl-2,4(1H,3H)-pyrimidinedione		C₁₁H₁₂N₄O₂	详情	详情
(IV)	43375	(E)-3-[3,5-di(tert-butyl)-4-hydroxyphenyl]-2-propenoic acid	22014-01-3	C₁₇H₂₄O₃	详情	详情

Extended Information