N'-(tert-butyl)-N,N-dimethyliminoformamide -Drug Synthesis Database

【结构式】

【分子编号】63418

【品名】N'-(tert-butyl)-N,N-dimethyliminoformamide

【CA登记号】

【分子式】C₇H₁₆N₂

【分子量】128.21752

【元素组成】C 65.57% H 12.58% N 21.85%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：

A new synthesis of [11C]-labeled MK-801 has been reported: The reaction of 10,11-dihydro-5H-dibenzo[a,d]cycloheptene (I) with N,N-dimethyl-N'-tert-butylformamidine in refluxing toluene gives the formamidine (II), which is alkylated with butyllithium and [11C]-labeled methyl iodide in ether-cyclohexane to yield the 5-methyl derivative (III). Finally, this compound is hydrolyzed with KOH in ethylene glycol.

参考文献中间体

合成目标

【1】 Kiesewetter, D.O.; Rice, K.C.; Finn, R.D.; Monn, J.A.; Synthesis of C-11-labeled (+/-)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]c yclohepten-5,10-imine [(+/-)-[C-11]MK801]. Appl Radiat Isot - Int J Radiat Appl Instrum Part A 1990, 41, 2, 139.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
	63418	N'-(tert-butyl)-N,N-dimethyliminoformamide	C₇H₁₆N₂	详情	详情
(I)	12082	16-Azatetracyclo[7.6.1.0(2,7).0(10,15)]hexadeca-2,4,6,10,12,14-hexaene	C₁₅H₁₃N	详情	详情
(II)	12083	N-[(E)-16-Azatetracyclo[7.6.1.0(2,7).0(10,15)]hexadeca-2,4,6,10,12,14-hexaen-16-ylmethylidene]-N-(tert-butyl)amine; N-[(E)-16-Azatetracyclo[7.6.1.0(2,7).0(10,15)]hexadeca-2,4,6,10,12,14-hexaen-16-ylmethylidene]-2-methyl-2-propanamine	C₂₀H₂₂N₂	详情	详情
(III)	12084	N-(tert-Butyl)-N-[(E)-(1-methyl-16-azatetracyclo[7.6.1.0(2,7).0(10,15)]hexadeca-2,4,6,10,12,14-hexaen-16-yl)methylidene]amine; 2-Methyl-N-[(E)-(1-methyl-16-azatetracyclo[7.6.1.0(2,7).0(10,15)]hexadeca-2,4,6,10,12,14-hexaen-16-yl)methylidene]-2-propanamine	C₂₁H₂₄N₂	详情	详情
(III)	45108	N-(tert-butyl)-N-[(E)-(1-methyl-16-azatetracyclo[7.6.1.0(2,7).0(10,15)]hexadeca-2,4,6,10,12,14-hexaen-16-yl)methylidene]amine; 2-methyl-N-[(E)-(1-methyl-16-azatetracyclo[7.6.1.0(2,7).0(10,15)]hexadeca-2,4,6,10,12,14-hexaen-16-yl)methylidene]-2-propanamine	C₂₁H₂₄N₂	详情	详情

Extended Information