【结 构 式】 |
【分子编号】63388 【品名】1-(1-{2-amino-3-[4-(methyloxy)phenyl]propanoyl}-4-phenyl-4-piperidinyl)-1-butanone 【CA登记号】 |
【 分 子 式 】C25H32N2O3 【 分 子 量 】408.54076 【元素组成】C 73.5% H 7.89% N 6.86% O 11.75% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(IV)Similarly, N-Boc-D-4-methoxyphenylalanine (I) is coupled to 4-butyryl-4-phenylpiperidine (II), yielding amide (III). After acidic Boc group cleavage in (III), the resultant amine (IV) is acylated by N-Boc-L-methylhistidine (V) to provide the dipeptide amide (VI). The N-Boc protecting group of (VI) is finally removed employing trifluoroacetic acid.
【1】 Herpin, T.F.; Yu, G.; Carlson, K.E.; Morton, G.C.; Wu, X.; Kang, L.; Tuerdi, H.; Khanna, A.; Tokarski, J.S.; Lawrence, R.M.; Macor, J.E.; Discovery of tyrosine-based potent and selective melanocortin-1 receptor small-molecule agonists with anti-inflammatory properties. J Med Chem 2003, 46, 7, 1123. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 16875 | (2S)-2-[(tert-Butoxycarbonyl)amino]-3-(4-methoxyphenyl)propionic acid; N-t-BOC-O-Methyl-L-tyrosine | 53267-93-9 | C15H21NO5 | 详情 | 详情 |
(II) | 63385 | 1-(4-phenyl-4-piperidinyl)-1-butanone | C15H21NO | 详情 | 详情 | |
(III) | 63387 | 1,1-dimethylethyl 2-(4-butanoyl-4-phenyl-1-piperidinyl)-1-{[4-(methyloxy)phenyl]methyl}-2-oxoethylcarbamate | C30H40N2O5 | 详情 | 详情 | |
(IV) | 63388 | 1-(1-{2-amino-3-[4-(methyloxy)phenyl]propanoyl}-4-phenyl-4-piperidinyl)-1-butanone | C25H32N2O3 | 详情 | 详情 | |
(V) | 63382 | N-{[(1,1-dimethylethyl)oxy]carbonyl}-1-methylhistidine | C12H19N3O4 | 详情 | 详情 | |
(VI) | 63386 | 1,1-dimethylethyl 2-[(2-(4-butanoyl-4-phenyl-1-piperidinyl)-1-{[4-(methyloxy)phenyl]methyl}-2-oxoethyl)amino]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2-oxoethylcarbamate | C37H49N5O6 | 详情 | 详情 |
Extended Information