6-isoquinolinamine; 6-isoquinolinylamine -Drug Synthesis Database

【结构式】

【分子编号】64245

【品名】6-isoquinolinamine; 6-isoquinolinylamine

【CA登记号】

【分子式】C₉H₈N₂

【分子量】144.176

【元素组成】C 74.98% H 5.59% N 19.43%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

Treatment of 6-aminoisoquinoline (I) with 1,1'-thiocarbonyldi-2(1H)-pyridone (II) provides the isothiocyanate (III). Subsequent condensation of (III) with 2-azidoacetophenone (IV) in the presence of triphenylphosphine affords the title oxazole derivative.

参考文献中间体

合成目标

【1】 Chen, P.; Norris, D.; Haslow, K.D.; Dhar, T.G.M.; Pitts, W.J.; Watterson, S.H.; Cheney, D.L.; Bassolino, D.A.; Fleener, C.A.; Rouleau, K.A.; Hollenbaugh, D.L.; Townsend, R.M.; Barrish, J.C.; Iwanowicz, E.J.; Identification of novel and potent isoquinoline aminooxazole-based IMPDH inhibitors. Bioorg Med Chem Lett 2003, 13, 7, 1345.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	64245	6-isoquinolinamine; 6-isoquinolinylamine	C₉H₈N₂	详情	详情
(II)	61696	1-{[2-oxo-1(2H)-pyridinyl]carbothioyl}-2(1H)-pyridinone	C₁₁H₈N₂O₂S	详情	详情
(III)	64246	6-isothiocyanatoisoquinoline; 6-isoquinolinyl isothiocyanate	C₁₀H₆N₂S	详情	详情
(IV)	26720	2-azido-1-phenyl-1-ethanone	C₈H₇N₃O	详情	详情

Extended Information