【结 构 式】 |
【分子编号】63291 【品名】(E)-3-(4-{[(3,4-dimethoxyphenyl)sulfonyl]amino}phenyl)-2-propenoyl chloride 【CA登记号】 |
【 分 子 式 】C17H16ClNO5S 【 分 子 量 】381.83648 【元素组成】C 53.47% H 4.22% Cl 9.28% N 3.67% O 20.95% S 8.4% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(IV)In a different method, p-aminocinnamic acid (I) is acylated by 3,4-dimethoxybenzenesulfonyl chloride (II) to yield sulfonamide (III). After activation of the carboxylic acid (III) with oxalyl chloride, the resultant acid chloride (IV) is condensed with hydroxylamine to furnish the target hydroxamic acid.
【1】 Harris, C.J.; Finn, P.W.; Kalvinsh, I.; Piskunova, I.; Starchenkov, I.; Watkins, C.J.; Romero-Martin, M.-R.; Moore, K.G.; Ritchie, J.; Loza, E.; Dikovska, K.; Gailite, V.; Vorona, M.; Adrianov, V.; Duffy, J.E.S. (TopoTarget A/S); Carbamic acid cpds. comprising a sulfonamide linkage as HDAC inhibitors. EP 1328510; WO 0230879 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 63290 | (E)-3-(4-aminophenyl)-2-propenoic acid | C9H9NO2 | 详情 | 详情 | |
(II) | 47469 | 3,4-dimethoxybenzenesulfonyl chloride | 23095-31-0 | C8H9ClO4S | 详情 | 详情 |
(III) | 63288 | (E)-3-(4-{[(3,4-dimethoxyphenyl)sulfonyl]amino}phenyl)-2-propenoic acid | C17H17NO6S | 详情 | 详情 | |
(IV) | 63291 | (E)-3-(4-{[(3,4-dimethoxyphenyl)sulfonyl]amino}phenyl)-2-propenoyl chloride | C17H16ClNO5S | 详情 | 详情 |
Extended Information