合成路线1

4-Chloro-5-formyl-2-phenylimidazole (I) is alkylated with 4-bromobenzyl bromide (II) in the presence of K2CO3 in DMF to produce the N-bromobenzyl imidazole (III). Subsequent Suzuki coupling between aryl bromide (III) and 5-isobutyl-2-[(N-tert-butyl)sulfonamido]thiophene-3-boronic acid (IV) affords the thienylphenyl derivative (V). The N-tert-butyl group is then removed by treatment with trifluoroacetic acid in the presence of anisole, yielding sulfonamide (VI). Displacement of the chloro substituent of (VI) with MeOH/NaOH furnishes the 4-methoxy imidazole (VII). Finally, condensation of sulfonamide (VII) with ethyl isocyanate gives rise to the target N-sulfonyl urea compound.