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【结 构 式】 
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【分子编号】63237 【品名】(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-17-glycoloyl-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl cyclopropanecarboxylate 【CA登记号】 |
【 分 子 式 】C26H33FO6 【 分 子 量 】460.5428232 【元素组成】C 67.81% H 7.22% F 4.13% O 20.84% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)Treatment of dexamethasone (I) with trimethyl orthocyclopropanecarboxylate (II) in the presence of p-toluenesulfonic acid gives the mixed orthoester (III), which, upon acidic hydrolysis with oxalic acid leads to the C-17 cyclopropanecarboxylate ester (IV). Subsequent esterification of (IV) with cyclohexanecarbonyl chloride (V) furnishes the desired dexamethasone diester.
| 【1】 Komoto, T.; Okawa, J.; Ogawa, Y.; Sato, S.; Taido, N.; Kuraishi, T. (SSP Co., Ltd.); Novel steroid derivs.. EP 0393658; JP 1990279694; US 5063222 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 40461 | (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-17-glycoloyl-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one | C22H29FO5 | 详情 | 详情 | |
| (II) | 63235 | 1-(trimethoxymethyl)cyclopropane; cyclopropyl(dimethoxy)methyl methyl ether | C7H14O3 | 详情 | 详情 | |
| (III) | 63236 | C27H35FO6 | 详情 | 详情 | ||
| (IV) | 63237 | (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-17-glycoloyl-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl cyclopropanecarboxylate | C26H33FO6 | 详情 | 详情 | |
| (V) | 17220 | cyclohexanecarbonyl chloride; Cyclohexanecarboxylic acid chloride | 2719-27-9 | C7H11ClO | 详情 | 详情 |
Extended Information