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【结 构 式】

【分子编号】63207

【品名】3'-methoxy[1,1'-biphenyl]-3-carboxamide

【CA登记号】

【 分 子 式 】C14H13NO2

【 分 子 量 】227.26276

【元素组成】C 73.99% H 5.77% N 6.16% O 14.08%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

Hydrolysis of 3-bromobenzonitrile (I) by means of sodium perborate leads to amide (II). Subsequent Suzuki coupling of 3-bromobenzamide (II) with 3-methoxyphenylboronic acid (III) furnishes the biphenyl compound (IV). The methyl ether group of (IV) is then cleaved employing BBr3 to yield phenol (V). This is finally coupled with cyclohexyl isocyanate (VI) to produce the title carbamate.

1 Kathuria, S.; Gaetani, S.; Fegley, D.; Valiño, M.; Duranti, A.; Tontini, A.; Mor, M.; Tarzia, G.; La Rana, G.; Calignano, A.; Giustino, A.; Tattoli, M.; Palmery, M.; Cuomo, V.; Piomelli, D.; Modulation of anxiety through blockade of anandamide hydrolysis. Nat Med 2003, 9, 1, 76.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 26573 3-bromobenzonitrile 6952-59-6 C7H4BrN 详情 详情
(II) 63206 3-bromobenzamide C7H6BrNO 详情 详情
(III) 29426 3-methoxyphenylboronic acid 10365-98-7 C7H9BO3 详情 详情
(IV) 63207 3'-methoxy[1,1'-biphenyl]-3-carboxamide C14H13NO2 详情 详情
(V) 63208 3'-hydroxy[1,1'-biphenyl]-3-carboxamide C13H11NO2 详情 详情
(VI) 18108 1-isocyanatocyclohexane; cyclohexyl isocyanate 3173-53-3 C7H11NO 详情 详情
Extended Information