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【结 构 式】 
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【分子编号】65783 【品名】2-Amino-5-thiazolethiol 【CA登记号】69950-00-1 |
【 分 子 式 】C3H4N2S2 【 分 子 量 】132.21024 【元素组成】C 27.25% H 3.05% N 21.19% S 48.51% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XIII)Alternatively, oxazole (VI) can be condensed with 2-amino-5-sulfanylthiazole (XIII) in refluxing ethanol to give thioether (IX). The intermediate 2-amino-5-sulfanylthiazole (XIII) can be obtained by reaction of 2-aminothiazole (XIV) with Br2 and KSCN to give the thiocyanato derivative (XV), which is finally reduced with NaBH4 in ethanol (4). Scheme 2.
| 【4】 Misra, N.R., Xiao, H., Kim, K.S. et al. N-(Cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent. J Med Chem 2004, 47(7): 1719-28. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VI) | 58417 | 5-(tert-butyl)-2-(chloromethyl)-1,3-oxazole | 224441-73-0 | C8H12ClNO | 详情 | 详情 |
| (IX) | 58420 | 5-({[5-(tert-butyl)-1,3-oxazol-2-yl]methyl}sulfanyl)-1,3-thiazol-2-amine; 5-({[5-(tert-butyl)-1,3-oxazol-2-yl]methyl}sulfanyl)-1,3-thiazol-2-ylamine | 224436-97-9 | C11H15N3OS2 | 详情 | 详情 |
| (XIII) | 65783 | 2-Amino-5-thiazolethiol | 69950-00-1 | C3H4N2S2 | 详情 | 详情 |
| (XIV) | 19795 | 2-Thiazolamine; 1,3-thiazol-2-amine; 1,3-thiazol-2-ylamine | 96-50-4 | C3H4N2S | 详情 | 详情 |
| (XV) | 64136 | 2-amino-1,3-thiazole-5-sulfenyl cyanide | 23056-10-2 | C4H3N3S2 | 详情 | 详情 |
Extended Information