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【结 构 式】

【分子编号】65778

【品名】 

【CA登记号】 

【 分 子 式 】C24H35N2O3

【 分 子 量 】399.55358

【元素组成】C 72.15% H 8.83% N 7.01% O 12.01%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XXIX)

In a further method, Mannich reaction of 4,4-dimethylcyclohexanone (XVII) with tert-butyl 4-piperazinobenzoate (XXVIII) and paraformaldehyde by means of HCl in tert-butanol affords the piperazinylmethyl-cyclohexanone (XXIX), which is further condensed with 4-chlorophenylmagnesium bromide (XXX), yielding carbinol (XXXI). Simultaneous dehydration of alcohol (XXXI) and cleavage of the tert-butyl ester in refluxing 6 M HCl gives carboxylic acid (IX) (3). Scheme 4.

3 Zhang, H., Zhou, J., Ha, C., Pei, D., Ding, K. An efficient synthesis of ABT-263, a novel inhibitor of antiapoptotic Bcl-2 proteins. Synthesis 2008, (15): 2398-404.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(IX) 65759     C26H31ClN2O2 详情 详情
(XVII) 65767 4,4-Dimethylcyclohexanone; 4,4-Dimethyl-1-cyclohexanone 4255-62-3 C8H14O 详情 详情
(XXVIII) 65777 2-Methyl-2-Propanyl 4-(1-Piperazinyl)Benzoate; tert-butyl 4-(1-Piperazinyl)Benzoate 187669-28-9 C15H22N2O2 详情 详情
(XXIX) 65778     C24H35N2O3 详情 详情
(XXX) 25127 bromo(4-chlorophenyl)magnesium 873-77-8 C6H4BrClMg 详情 详情
(XXXI) 65779     C30H40ClN2O3 详情 详情
Extended Information