3-(2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzothiazin-7-yl)-5-(azidomethyl)-1,3-oxazolidin-2-one -Drug Synthesis Database

【结构式】

【分子编号】64128

【品名】3-(2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzothiazin-7-yl)-5-(azidomethyl)-1,3-oxazolidin-2-one

【CA登记号】

【分子式】C₁₅H₁₇N₅O₂S

【分子量】331.39848

【元素组成】C 54.37% H 5.17% N 21.13% O 9.66% S 9.68%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XIII)

The mesylate group in (XII) is displaced with NaN3 to yield azide (XIII), which is further reduced to the primary amine (XIV) employing PPh3. Finally, reaction of amine (XIV) with thiophosgene, followed by methanol gives rise to the target thiocarbamate derivative.

参考文献中间体

合成目标

【1】 Selvakumar, N.; Reddy, B.Y.; Kumar, G.S.; Khera, M.K.; Srinivas, D.; Kumar, M.S.; Das, J.; Iqbal, J.; Trehan, S.; SAR studies on certain conformationally constrained oxazolidinones. 42nd Intersci Conf Antimicrob Agents Chemother (Sept 27 2002, San Diego) 2002, Abst F-1324.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(XII)	64127	[3-(2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzothiazin-7-yl)-2-oxo-1,3-oxazolidin-5-yl]methyl methanesulfonate	C₁₆H₂₀N₂O₅S₂	详情	详情
(XIII)	64128	3-(2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzothiazin-7-yl)-5-(azidomethyl)-1,3-oxazolidin-2-one	C₁₅H₁₇N₅O₂S	详情	详情
(XIV)	64129	5-(aminomethyl)-3-(2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzothiazin-7-yl)-1,3-oxazolidin-2-one	C₁₅H₁₉N₃O₂S	详情	详情

Extended Information