6-nitro-N-(4-phenoxyphenethyl)-4-quinazolinamine; N-(6-nitro-4-quinazolinyl)-N-(4-phenoxyphenethyl)amine -Drug Synthesis Database

【结构式】

【分子编号】63329

【品名】6-nitro-N-(4-phenoxyphenethyl)-4-quinazolinamine; N-(6-nitro-4-quinazolinyl)-N-(4-phenoxyphenethyl)amine

【CA登记号】

【分子式】C₂₂H₁₈N₄O₃

【分子量】386.41008

【元素组成】C 68.38% H 4.7% N 14.5% O 12.42%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

Chlorination of 6-nitro-4-quinazolone (I) in refluxing SOCl2 affords 4-chloro-6-nitroquinazoline (II), which is then condensed with 4-phenoxyphenethylamine (III) to furnish the 4-aminoquinazoline (IV). Finally, nitro group reduction employing iron powder and acetic acid gives rise to the title compound.

参考文献中间体

合成目标

【1】 Tobe, M.; Isobe, Y.; Tomizawa, H.; Nagasaki, T.; Takahashi, H.; Fukazawa, T.; Hayashi, H.; Discovery of quinazolines as a novel structural class of potent inhibitors of NF-kappaB activation. Bioorg Med Chem 2003, 11, 3, 383.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	34444	6-nitro-4(3H)-quinazolinone	C₈H₅N₃O₃	详情	详情
(II)	63327	4-chloro-6-nitroquinazoline	C₈H₄ClN₃O₂	详情	详情
(III)	63328	2-(4-phenoxyphenyl)-1-ethanamine; 4-phenoxyphenethylamine	C₁₄H₁₅NO	详情	详情
(IV)	63329	6-nitro-N-(4-phenoxyphenethyl)-4-quinazolinamine; N-(6-nitro-4-quinazolinyl)-N-(4-phenoxyphenethyl)amine	C₂₂H₁₈N₄O₃	详情	详情

Extended Information