　 -Drug Synthesis Database

【结构式】

【分子编号】63046

【品名】　

【CA登记号】

【分子式】C₁₆H₁₃ClN₂O₂

【分子量】300.7442

【元素组成】C 63.9% H 4.36% Cl 11.79% N 9.31% O 10.64%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

Acylation of the 2-aminobenzophenone (I) with bromoacetyl bromide (II) provides the bromoacetamide (III). Subsequent treatment of (III) with ammonia leads to the benzodiazepinone (IV). Methylation of the lactam N with iodomethane in the presence of K2CO3 gives rise to (V). The potassium enolate of benzodiazepinone (V) is then alkylated by 2-(bromomethyl)naphthalene (VI) to furnish the naphthylmethyl derivative (VII). Finally, methyl ether cleavage using AlBr3 in ethanethiol provides the target phenolic compound

参考文献中间体

合成目标

【1】 Kim, K.; Volkman, S.K.; Ellman, J.A.; Synthesis of 3-substituted 1,4-benzodiazepin-2-ones. J Braz Chem Soc 1998, 9, 4, 375.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	63044			C₁₄H₁₂ClNO₂	详情	详情
(II)	14005	2-Bromoacetyl bromide; Bromoacetyl bromide	598-21-0	C₂H₂Br₂O	详情	详情
(III)	63045			C₁₆H₁₃BrClNO₃	详情	详情
(IV)	63046			C₁₆H₁₃ClN₂O₂	详情	详情
(V)	63043			C₁₇H₁₅ClN₂O₂	详情	详情
(VI)	35612	2-(bromomethyl)naphthalene	939-26-4	C₁₁H₉Br	详情	详情
(VII)	63042			C₂₈H₂₃ClN₂O₂	详情	详情

Extended Information