(2S)-3-({2-[(4-[1-(tert-butoxycarbonyl)-4-piperidinyl]-2-{2-[1-(tert-butoxycarbonyl)-4-piperidinyl]ethyl}butanoyl)amino]acetyl}amino)-2-[(2-naphthylsulfonyl)amino]propanoic acid -Drug Synthesis Database

【结构式】

【分子编号】63031

【品名】(2S)-3-({2-[(4-[1-(tert-butoxycarbonyl)-4-piperidinyl]-2-{2-[1-(tert-butoxycarbonyl)-4-piperidinyl]ethyl}butanoyl)amino]acetyl}amino)-2-[(2-naphthylsulfonyl)amino]propanoic acid

【CA登记号】

【分子式】C₄₁H₆₁N₅O₁₀S

【分子量】816.02904

【元素组成】C 60.35% H 7.53% N 8.58% O 19.61% S 3.93%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XV)

Hydrolysis of ethyl ester (XIV) employing LiOH affords the carboxylic acid (XV). The N-Boc protecting groups are finally removed by treatment with HCl in EtOAc to provide the title compound.

参考文献中间体

合成目标

【1】 Lesur, B.; Henry, M.; Yue, C.; Giboulot, T. (Laboratoires L. Lafon); Bispiperidines as antithrombotic agents. EP 1098878; FR 2781223; JP 2002520393; US 6333338; WO 0003986 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(XIV)	63029	tert-butyl 4-[5-[1-(tert-butoxycarbonyl)-4-piperidinyl]-3-({[2-({(2S)-3-ethoxy-2-[(2-naphthylsulfonyl)amino]-3-oxopropyl}amino)-2-oxoethyl]amino}carbonyl)pentyl]-1-piperidinecarboxylate		C₄₃H₆₅N₅O₁₀S	详情	详情
(XV)	63031	(2S)-3-({2-[(4-[1-(tert-butoxycarbonyl)-4-piperidinyl]-2-{2-[1-(tert-butoxycarbonyl)-4-piperidinyl]ethyl}butanoyl)amino]acetyl}amino)-2-[(2-naphthylsulfonyl)amino]propanoic acid		C₄₁H₆₁N₅O₁₀S	详情	详情

Extended Information