【结 构 式】 |
【分子编号】63001 【品名】methyl 6-[4-(methyloxy)-3-tricyclo[3.3.1.1~3,7~]dec-1-ylphenyl]-2-naphthalenecarboxylate; methyl 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoate 【CA登记号】 |
【 分 子 式 】C29H30O3 【 分 子 量 】426.5554 【元素组成】C 81.66% H 7.09% O 11.25% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(III)The bromination of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid methyl ester (I) with Br2 in dichloromethane gives the dibromo derivative (II), which is hydrogenated with tritium gas over Pd/C in THF containing TEA to yield the bis tritiated ester (III). Finally, ester (III) is hydrolyzed with NaOH in refluxing methanol to afford the target tritiated naphthoic acid.
【1】 Shroot, B.; Darmon, M. (Laboratoires Galderma SA); Novel tritium marked cpds., its preparation and application for finding of retinoid nuclear receptors. CA 2021550; EP 0409740; FR 2649976; JP 1991063246; US 5073361; US 5149631 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 62999 | methyl 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoate; methyl 6-[4-(methyloxy)-3-tricyclo[3.3.1.1~3,7~]dec-1-ylphenyl]-2-naphthalenecarboxylate | C29H30O3 | 详情 | 详情 | |
(II) | 63000 | methyl 6-[3-(1-adamantyl)-5-bromo-4-methoxyphenyl]-5-bromo-2-naphthoate; methyl 6-[3-(1-adamantyl)-5-bromo-4-methoxyphenyl]-5-bromo-2-naphthoate | C29H28Br2O3 | 详情 | 详情 | |
(III) | 63001 | methyl 6-[4-(methyloxy)-3-tricyclo[3.3.1.1~3,7~]dec-1-ylphenyl]-2-naphthalenecarboxylate; methyl 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoate | C29H30O3 | 详情 | 详情 |
Extended Information