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【结 构 式】

【分子编号】63001

【品名】methyl 6-[4-(methyloxy)-3-tricyclo[3.3.1.1~3,7~]dec-1-ylphenyl]-2-naphthalenecarboxylate; methyl 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoate

【CA登记号】

【 分 子 式 】C29H30O3

【 分 子 量 】426.5554

【元素组成】C 81.66% H 7.09% O 11.25%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

The bromination of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid methyl ester (I) with Br2 in dichloromethane gives the dibromo derivative (II), which is hydrogenated with tritium gas over Pd/C in THF containing TEA to yield the bis tritiated ester (III). Finally, ester (III) is hydrolyzed with NaOH in refluxing methanol to afford the target tritiated naphthoic acid.

1 Shroot, B.; Darmon, M. (Laboratoires Galderma SA); Novel tritium marked cpds., its preparation and application for finding of retinoid nuclear receptors. CA 2021550; EP 0409740; FR 2649976; JP 1991063246; US 5073361; US 5149631 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 62999 methyl 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoate; methyl 6-[4-(methyloxy)-3-tricyclo[3.3.1.1~3,7~]dec-1-ylphenyl]-2-naphthalenecarboxylate C29H30O3 详情 详情
(II) 63000 methyl 6-[3-(1-adamantyl)-5-bromo-4-methoxyphenyl]-5-bromo-2-naphthoate; methyl 6-[3-(1-adamantyl)-5-bromo-4-methoxyphenyl]-5-bromo-2-naphthoate C29H28Br2O3 详情 详情
(III) 63001 methyl 6-[4-(methyloxy)-3-tricyclo[3.3.1.1~3,7~]dec-1-ylphenyl]-2-naphthalenecarboxylate; methyl 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoate C29H30O3 详情 详情
Extended Information