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【结 构 式】

【分子编号】62982

【品名】N''-(5-bromo-6-quinoxalinyl)guanidine

【CA登记号】

【 分 子 式 】C9H8BrN5

【 分 子 量 】266.10022

【元素组成】C 40.62% H 3.03% Br 30.03% N 26.32%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:AGN-191383

Several degradation products and metabolites of brimonidine have been synthesized: 1) The reaction of 5-bromoquinoxalin-6-amine (I) with cyanamide (II) and HCl in refluxing dioxane gives N2-(5-bromoquinoxalin-6-yl)guanidine (AGN-191383). 2) The reaction of AGN-191383 with 1,1'-oxalyldiimidazole (III) and dimethylaminopyridine (DMAP) in pyridine yields 2-(5-bromoquinoxalin-6-ylimino)imidazolidine-4,5-dione (AGN-192597). 3) The reaction of AGN-191383 with sodium iodoacetate (IV) in DMSO and then acidification with HCl affords 2-[N2-(5-bromoquinoxalin-6-yl)guanidino]acetic acid (AGN-192614).

1 Tang-Liu, D.; Burke, J.; Garst, M.; Harcourt, D.; Acheampong, A.; Breau, A.; Munk, S.A.; Wong, H.; Lai, R.; Wheeler, L.; Synthesis and characterization of degradation products and metabolites of brimonidine - A potent alpha2 adrenergic agonist. 211th ACS Natl Meet (March 24-28, New Orleans) 1996, Abst MEDI 021.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
AGN-191383 62982 N''-(5-bromo-6-quinoxalinyl)guanidine C9H8BrN5 详情 详情
AGN-192614 62983 2-({amino[(5-bromo-6-quinoxalinyl)imino]methyl}amino)acetic acid C11H10BrN5O2 详情 详情
AGN-192597 62984 2-[(5-bromo-6-quinoxalinyl)imino]-4,5-imidazolidinedione C11H6BrN5O2 详情 详情
(I) 10328 5-Bromo-6-quinoxalinamine; 5-Bromo-6-quinoxalinylamine C8H6BrN3 详情 详情
(III) 10329 1,2-Di(1H-imidazol-1-yl)-1,2-ethanedione; 1,1'-Oxalyldiimidazole 18637-83-7 C8H6N4O2 详情 详情
(IV) 62985 sodium 2-iodoacetate C2H2INaO2 详情 详情
Extended Information